16458-22-3Relevant academic research and scientific papers
First intermolecular palladium catalyzed arylation of an unfunctionalized aromatic hydrocarbon
Dyker, Gerald,Borowski, Stefan,Heiermann, J?rg,K?rning, Jutta,Opwis, Klaus,Henkel, Gerald,K?ckerling, Martin
, p. 108 - 111 (2007/10/03)
Azulene is arylated by iodobenzene and by 4-nitro-chlorobenzene under palladium catalysis at the electron-rich 1-position.
ALKYLATION AND ACYLATION OF AZULENE IN THE PRESENCE OF COPPER
Nefedov, V. A.,Tarygina, L. K.
, p. 1724 - 1728 (2007/10/03)
In the presene of copper powder organic halogen derivaties react with azulene to form 1-R- and 1,3-R2-=azulenes.The acid chlorides are most active in the series R = PhCO, PhCH=CHCO, Me2NCO, PhCH2, H2CCCH2, Bu, and EtOOCCH2.With copper phenylacetylide (insted of copper) it is possible to obtain allyl- and propargylazulenes with high yields under mild conditions.In reaction with copper and azulene aryl halides dimerize to ArAr, but thhey do not substitute hydrogen in the azulene.
A Versatile Synthetic Method of 1-Alkylazulenes and Azulene by the Reactions of 3-Methoxycarbonyl-2H-cycloheptafuran-2-one with in situ Generated Enamines
Yasunami, Masafumi,Miyoshi, Shiro,Kanegae, Noriko,Takase, Kahei
, p. 892 - 899 (2007/10/02)
Methyl 3-alkylazulene-1-carboxylates were synthesized in high yields by the reaction of 3-methoxycarbonyl-2H-cycloheptafuran-2-one with in situ generated morpholine enamines of aldehydes.Treatment of the esters with 100percent phosphoric acid gave 1-alkylazulenes in excellent yields.Azulene was also synthesized in a good yield via methyl azulene-1-carboxylate with a modification of this method.
