50603-71-9Relevant articles and documents
Synthesis, characterization, and antipeptic activity of a novel surfactant having an azulene moiety
Fujio, Katsuhiko,Kobayashi, Hideharu,Ozeki, Sumio,Fujimori, Kunihide
, p. 1272 - 1273 (2006)
A novel surfactant having an azulene moiety, sodium 3-decyl-1- azulenesulfonate (CIOAS), has been synthesized. The surface-activity of C10AS is lower than that of its structural isomer, sodium 4-decyl-1-naphthalenesulfonate (C10NS), probably caused by the higher hydrophilicity of C10AS due to the dipole moment of azulene moiety. C10AS exhibits the higher antipeptic activity than the propyl derivative (C3AS) below its critical micelle concentration. Copyright
Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators
Montgomery, Mark,Rendine, Stefano,Zimmer, Christoph T.,Elias, Jan,Schaetzer, Jürgen,Pitterna, Thomas,Benfatti, Fides,Skaljac, Marisa,Bigot, Aurélien
, p. 2297 - 2312 (2022/01/20)
The development of novel and safe insecticides remains an important need for a growing world population to protect crops and animal and human health. New chemotypes modulating the insect nicotinic acetylcholine receptors have been recently brought to the agricultural market, yet with limited understanding of their molecular interactions at their target receptor. Herein, we disclose the first crystal structures of these insecticides, namely, sulfoxaflor, flupyradifurone, triflumezopyrim, flupyrimin, and the experimental compound, dicloromezotiaz, in a double-mutated acetylcholine-binding protein which mimics the insect-ion-channel orthosteric site. Enabled by these findings, we discovered novel pharmacophores with a related mode of action, and we describe herein their design, synthesis, and biological evaluation.
Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity.
Rekka, Eleni,Chrysselis, Michael,Siskou, Ioanna,Kourounakis, Angeliki
, p. 904 - 907 (2007/10/03)
The relationship between free radicals and acute or chronic inflammation has been well established. We have previously reported the significant antioxidant activity of the natural azulene derivatives chamazulene and guaiazulene. Furthermore, some syntheti