16459-35-1 Usage
Uses
Used in Organic Chemistry Research:
5-Amino-1-(4-Nitro-Phenyl)-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester is used as a research compound for exploring its chemical properties and potential applications in organic chemistry. Its unique structure allows for various chemical reactions and modifications, making it a valuable tool for scientists studying organic compounds and their interactions.
Used in Pharmaceutical Research:
Although not commonly documented, 5-Amino-1-(4-Nitro-Phenyl)-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester may have potential applications in the development of pharmaceuticals. Its multiple functional groups could be utilized in the synthesis of new drug molecules or as intermediates in the production of existing medications.
Used in Material Science:
The unique structure of 5-Amino-1-(4-Nitro-Phenyl)-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester may also find applications in material science, where its properties could be harnessed to develop new materials with specific characteristics. For example, its amino and carboxyl groups could be used to form cross-linking networks in polymers or to create self-assembling structures.
Check Digit Verification of cas no
The CAS Registry Mumber 16459-35-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,5 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16459-35:
(7*1)+(6*6)+(5*4)+(4*5)+(3*9)+(2*3)+(1*5)=121
121 % 10 = 1
So 16459-35-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H12N4O4/c1-2-20-12(17)10-7-14-15(11(10)13)8-3-5-9(6-4-8)16(18)19/h3-7H,2,13H2,1H3
16459-35-1Relevant academic research and scientific papers
The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition
Chen, Hui,Wang, Bin,Li, Peng,Yan, Hong,Li, Gang,Huang, Haihong,Lu, Yu
supporting information, (2021/03/26)
In this study, a series of sulfonamide compounds was designed and synthesized through the systematic optimization of the antibacterial agent sulfaphenazole for the treatment of Mycobacterium tuberculosis (M. tuberculosis). Preliminary results indicate that the 4-aminobenzenesulfonamide moiety plays a key role in maintaining antimycobacterial activity. Compounds 10c, 10d, 10f and 10i through the optimization on phenyl ring at the R2 site on the pyrazole displayed promising antimycobacterial activity paired with low cytotoxicity. In particular, compound 10d displayed good activity (MIC = 5.69 μg/mL) with low inhibition of CYP 2C9 (IC50 > 10 μM), consequently low potential risk of drug-drug interaction. These promising results provide new insight into the combination regimen using sulfonamide as one component for the treatment of M. tuberculosis.
