16473-39-5

Basic information

• Product Name: Benzene, 1-(fluoromethyl)-4-methoxy-
• Synonyms: 4-methoxybenzyl fluoride;methoxy-4 fluorure de benzyle;Benzene,1-(fluoromethyl)-4-methoxy;p-methoxybenzyl fluoride;p-Methoxy-benzylfluorid
• CAS NO: 16473-39-5
• Molecular Formula: C8H9FO
• Molecular Weight: 140.157
• Mol File: 16473-39-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(fluoromethyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(fluoromethyl)-4-methoxy-(16473-39-5)
• EPA Substance Registry System: Benzene, 1-(fluoromethyl)-4-methoxy-(16473-39-5)

Safety Data

• Hazardous Substances Data: 16473-39-5(Hazardous Substances Data)

Upstream product

• 101803-60-5 tert-butyl((4-methoxybenzyl)oxy)dimethylsilane 
• 5720-07-0 4-methoxyphenylboronic acid 
• 373-53-5 fluoroiodomethane 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 
• 696-62-8 para-iodoanisole 
• 1365765-67-8 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone 
• 1415115-16-0 C₁₃H₁₂FNO₃S 
• 29180-19-6 4-methoxybenzyl carbocation 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2393-23-9 4-methoxy-benzylamine 
• 14629-56-2 trimethyl(4-methoxybenzyloxy)silane 
• 104-93-8 p-methylanizole 

Downstream Products

• 105-13-5 4-Methoxybenzyl alcohol 

Relevant articles and documents

Metal-free reduction of the greenhouse gas sulfur hexafluoride, formation of SF5 containing ion pairs and the application in fluorinations

A protocol for the fast and selective two-electron reduction of the potent greenhouse gas sulfur hexafluoride (SF6) by organic electron donors at ambient temperature has been developed. The reaction yields solid ion pairs consisting of donor di

METHOD AND REAGENT FOR DEOXYFLUORINATION

A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.

Fluorination reagent and deoxygenation fluorination method

In order to overcome the problems of high cost and poor stability of the existing deoxidation fluorination reagent, the invention provides a fluorination reagent. The fluorination reagent comprises acation M and an anion, and the anion is selected from one or more of the following perfluoropolyether chain carboxylic acid anions: CF3 (OCF2) nCO2, and n is selected from 1-10. Meanwhile, the invention further discloses a deoxidation fluorination method. The fluorination reagent provided by the invention has the advantages that the materials are easy to obtain, the fluorination products can beobtained at higher yield for various alcohol substrates, and the universality for different alcohol substrates is better.