Journal of Organic Chemistry p. 2423 - 2427 (1984)
Update date:2022-08-03
Topics:
Jarvis, Bruce B.
Vrudhula, Vivekananda M.
Dishong, Dennis M.
Gokel, George W.
A series of lariat ethers (derivatives of 18-crown-6, 15-crown-5, and 12-crown-4) bearing pendant epoxy groups has been prepared and the homogeneous stability (binding) constants (Ks) with Na+ and K+ in MeOH have been measured.The epoxy groups appear to have only a marginal influence on complexation of K+ in the larger ring compounds and do not enhance Na+ binding.These epoxy lariat ethers exhibit no in vivo activity against P388 mouse leukemia at dose levels of 128 mg/kg and below.
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