164848-06-0

Basic information

• Product Name: (4R,5S)-(5-tert-butyldimethylsilyloxymethyl)-4-(hydroxymethyl)tetrahydrofuran-2-one
• Synonyms: (4R,5S)-(5-tert-butyldimethylsilyloxymethyl)-4-(hydroxymethyl)tetrahydrofuran-2-one
• CAS NO: 164848-06-0
• Molecular Weight: 260.406
• Mol File: 164848-06-0.mol

Chemical Properties

• CAS DataBase Reference: (4R,5S)-(5-tert-butyldimethylsilyloxymethyl)-4-(hydroxymethyl)tetrahydrofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-(5-tert-butyldimethylsilyloxymethyl)-4-(hydroxymethyl)tetrahydrofuran-2-one(164848-06-0)
• EPA Substance Registry System: (4R,5S)-(5-tert-butyldimethylsilyloxymethyl)-4-(hydroxymethyl)tetrahydrofuran-2-one(164848-06-0)

Safety Data

• Hazardous Substances Data: 164848-06-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 105122-15-4 (5S)-5-(tert-butyldimethylsilanyloxymethyl)-5H-furan-2-one 
• 119-61-9 benzophenone 

Downstream Products

• 188031-26-7 Benzoic acid (2S,3R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-tetrahydro-furan-3-ylmethyl ester 
• 188031-28-9 Benzoic acid (2S,3R)-5-acetoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-ylmethyl ester 
• 188031-30-3 Benzoic acid (2S,3R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-ylmethyl ester 

Relevant articles and documents

Photocatalysed Addition of Alcohols to 5-Substituted 2,5-Dihydrofuran-2-ones: Novel Synthesis of (3'R)-2',3'-Dideoxy-3'-hydroxymethyl Nucleosides

Methanol and propan-2-ol add in a regiospecific and higly stereocontrolled fashion to 5-substituted 2,5-dihydrofuran-2-ones (butenolides) under irradiation.The photoadducts with methanol have been converted into a number of (3'R)-2',3'-dideoxy-3'-hydroxymethyl nucleosides.