105122-15-4Relevant articles and documents
Catalytic ferrier rearrangement of unsaturated nucleosides
Linker, Torsten,Sommermann, Thomas,Gimisis, Thanasis,Chatgilialoglu, Chryssostomos
, p. 9637 - 9638 (1998)
The attempted intermolecular addition of malonyl radicals to 1',2'- unsaturated nucleosides has led to the unexpected formation of furanones. Thus, only catalytic amounts of ceric(IV) ammonium nitrate (CAN), induce a Ferrier rearrangement. The unsaturated lactone was isolated in good yield and can serve as a precursor for the synthesis of optically active products.
Synthesis and antiviral activity of the cyclopropano homolog of 2,3- didehydro-2,3-dideoxythymidine
Sard
, p. 2321 - 2328 (1994)
2,3-Didehydro-2,3-dideoxythymidine is among the nucleoside analogs which have been shown to be clinically useful as anti-HIV agents. Its 2,3- cyclopropano analog has now been synthesized and evaluated. However, the title compound is inactive against HIV.
A facile entry to bicyclic systems from L-glutamic acid
Frieman, Bryan A.,Bock, Charles W.,Bhat, Krishna L.
, p. 2099 - 2108 (2001)
An efficient synthesis of bicyclic heterocycles has been realized from L-glutamic acid. The key step is the construction of the pyrrole ring in a single step, using tosylmethyl isocyanide (TosMIC) methodology. Structures of reaction intermediates and final products were investigated using density functional theory calculations.
The use of d-mannitol-derived C2-symmetric trienes in tandem metathesis reactions towards valuable lactones
Riache, Nassima,Blond, Alain,Nay, Bastien
, p. 10853 - 10859 (2008)
Chiral lactones were synthesized from d-mannitol. C2-symmetric triene precursors were constructed with a central relay-olefin allowing the key domino ring-closing metathesis to be achieved. It led to the symmetrical cleavage of the substrate and to the formation of 2 mol of the desired 5- or 6-membered lactone. Attempts to form 7-membered lactones thus far only led to 14-membered macrodiolides instead.
Process for Preparing Beraprost Intermediate
-
Paragraph 0160; 0161, (2018/01/05)
The present invention relates to a method of producing an intermediate necessary for the production of 314d isomer of beraprost in a high yield and in mild reaction conditions. According to the present invention, the method can produce a compound of chemical formula 3 in a high yield, which is a major intermediate necessary for the production of 314d isomer of beraprost, in mild reaction conditions.COPYRIGHT KIPO 2017