16492-49-2

Usage

Chemical Class

Pyrazole derivatives

Structure

Heterocyclic organic compound with a five-membered ring and two nitrogen atoms

Common Uses

Building block in pharmaceutical research for the synthesis of biologically active compounds

Potential Applications

Development of new drugs in medicinal chemistry

Industrial Uses

Production of specialized chemicals and materials

Versatility

Potential applications in both pharmaceutical and industrial sectors.

Upstream product

• 7188-89-8 5-methyl-1,3-diphenyl-1H-pyrazole 
• 100-34-5 benzene diazonium chloride 
• 71-43-2 benzene 
• 396717-13-8 1-phenyl-2-(1-phenylbut-3-en-1-yl)hydrazine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 371226-35-6 3-methyl-1,5-diphenyl-5-(phenyl-hydrazono)-pentan-1-one 
• 413624-72-3 1,3-diphenyl-5-(phenylselanylmethyl)-4,5-dihydro-1H-pyrazole 
• 495-41-0 1-phenylbut-2-en-1-one 
• 100-63-0 phenylhydrazine 

Relevant academic research and scientific papers

Transformations of mono- and bisphenylhydrazones of aliphatic-aromatic 1,5-diketones under the conditions of the fischer reaction

The mono- and bisphenylhydrazones of 3-R-1,5-diphenylpentane-1,5-diones were obtained, and their transformations in the Fischer indole synthesis under various conditions were studied. It was shown that 4-R-2,6-diphenylpyridines, 2-phenylindole, and 5-R-1,-3-diphenyl-Δ2-pyrazolines are formed as the main products in addition to the 3-R-1-phenyl-3-(2-phenyl-3-indolyl)propan-1-ones or their phenylhydrazones produced as a result of indolization. The ways of formation of these compounds are discussed. Some transformations of the obtained ketones were studied.

Synthesis of pyrazolidine, 1-pyrazoline, 2-pyrazoline derivatives by selenium-induced cyclization of homoallylhydrazines

The PhSeBr-induced cyclization of N′-but-3-en-1-yl ethoxycarbonylhydrazines 1, phenylhydrazines 2 and dimethylhydrazines 3 has been studied. A 5-exo-trig ring closure occurred in each case and phenylselanylmethyl-pyrazolidines 4, 2-pyrazolines 5 and 10, 1-pyrazolines 8 and pyrazolidinium bromides 11 were synthesized. Radical deselenenylation has allowed the preparation of 5-methylpyrazolidines 12 and 5-methyl-2-pyrazolines 13 and 14. Decomposition of the dibromoselenuranes derived from 2-pyrazolines 5 and 10 afforded bromomethyl derivatives. With 1-phenyl-2-pyrazolines 10, an electrophilic p-halogenation of the phenyl nucleus was observed.