164929-15-1Relevant articles and documents
A one-step photocatalytic synthesis of 2-(trifluoromethyl)butyrolactones
Reineke, Ninja,Zaidi, Naveed A.,Mitra, Manju,O'Hagan, David,Batsanov, Andrei S.,Howard, Judith A. K.,Naumov, Dmitri Y.
, p. 147 - 150 (1996)
An efficient one-step procedure is described for the synthesis of 2-(trifluoromethyl)butyrolactone 1 and 4-substituted 2-(trifluoromethyl)butyrolactones by the photocatalytic conjugate addition of primary and secondary alcohols to 2-(trifluoromethyl)acrylic acid 6. With the exception of methanol, the reactions are conducted without a photosensitiser. The diastereoisomers of compounds 8 and 10 were separable by chromatography and their relative configurations were established unambiguously by X-ray analyses of suitable crystals.