16495-81-1Relevant academic research and scientific papers
Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes
Upare, Atul,Sathyanarayana, Pochampalli,Kore, Ranjith,Sharma, Komal,Bathula, Surendar Reddy
, p. 2430 - 2433 (2018/05/23)
Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.
One-pot and three-component synthesis of substituted pyrimidines catalysed by boron sulfuric acid under solvent-free conditions
Soheilizad, Mehdi,Adiba, Mehdi,Sajjadifarb, Sami
, p. 524 - 527 (2014/12/10)
An efficient, simple and one-pot synthesis of pyrimidine derivatives by a three-component reaction of ketones, triethyl orthoformate, and ammonium acetate in the presence of boron sulfuric acid as a reusable and efficient catalyst under solvent-free conditions is reported. The reusability of catalyst, simplicity of the starting materials, short reaction time, one-pot, and good yields of products are the main advantages.
Novel synthesis of bihetaryl compounds
Nishiwaki, Nagatoshi,Yamashita, Keiko,Azuma, Mayumi,Adachi, Tomoko,Tamura, Mina,Ariga, Masahiro
, p. 1996 - 2000 (2007/10/03)
The ring transformation of nitropyrimidinone 1 with acetophenone derivatives 2 affords two kinds of azaheterocyclic compounds, 4-phenylpyrimidines 3 and 3-nitro-6-phenyl-2-pyridones 4. On the basis of the relationship between electronic properties of the substituent and ratios of products, a plausible reaction mechanism is provided. Furthermore, the present reaction could be applied to heterocyclic ketones giving bihetaryl compounds.
THE NITRATION OF PHENYLPYRIMIDINES
Adams, David,Dosanjh, Mohinder,Hurst, Derek T.
, p. 1989 - 1993 (2007/10/02)
The nitration of 4-phenylpyrimidine using nitric acid/sulphuric acid at 0 deg C has been shown to give 4-o-nitrophenylpyrimidine and 4-m-nitro-phenylpyrimidine in the ratio of 4:6.Under similar conditions 5-bromo-2-phenylpyrimidine has given 5-bromo-2o-nitrophenyl and 5-bromo-2-m-nitrophenylpyrimidine in the ratio of 3:7 and 5-chloro-2-phenylpyrimidine has given the 2-o-nitrophenyl and the 2-m-nitrophenyl isomers in the ratio of 3.5:6.5.
