16495-81-1

Basic information

• Product Name: Pyrimidine, 4-(3-nitrophenyl)-
• CAS NO: 16495-81-1
• Molecular Formula: C10H7N3O2
• Molecular Weight: 201.184
• Mol File: 16495-81-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 4-(3-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-(3-nitrophenyl)-(16495-81-1)
• EPA Substance Registry System: Pyrimidine, 4-(3-nitrophenyl)-(16495-81-1)

Safety Data

• Hazardous Substances Data: 16495-81-1(Hazardous Substances Data)

Upstream product

• 3438-48-0 4-phenylpyrimidine 
• 121-89-1 3-Nitroacetophenone 
• 7471-32-1 m-nitroacetophenone oxime 
• 149-73-5 trimethyl orthoformate 
• 2305-87-5 4-phenylpyrimidin-2-amine 
• 38675-31-9 4-phenyl-1H-pyrimidin-2-one 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 
• 15397-33-8 3-Oxo-3-phenylpropanal 
• 98-86-2 acetophenone 
• 13036-50-5 2-chloro-4-phenylpyrimidine 

Relevant articles and documents

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.

Novel synthesis of bihetaryl compounds

The ring transformation of nitropyrimidinone 1 with acetophenone derivatives 2 affords two kinds of azaheterocyclic compounds, 4-phenylpyrimidines 3 and 3-nitro-6-phenyl-2-pyridones 4. On the basis of the relationship between electronic properties of the substituent and ratios of products, a plausible reaction mechanism is provided. Furthermore, the present reaction could be applied to heterocyclic ketones giving bihetaryl compounds.