16499-64-2

Usage

Uses

Used in Pharmaceutical Industry:
4-chloro-6-(trifluoromethyl)quinazoline is used as a potential candidate for the development of new drugs due to its distinctive chemical structure and properties. Its ability to interact with biological targets makes it a promising compound for medicinal chemistry.
Used in Chemical Synthesis:
As a reagent, 4-chloro-6-(trifluoromethyl)quinazoline is utilized in the synthesis of other organic compounds. Its unique functional groups facilitate various chemical reactions, contributing to the creation of a wide range of products in the chemical industry.
Used in Organic Chemistry Research and Development:
4-chloro-6-(trifluoromethyl)quinazoline is employed as a building block for the creation of novel organic compounds. Its unique structure and properties make it an interesting subject for research in organic chemistry, potentially leading to the discovery of new reactions, compounds, and applications.

InChI:InChI=1/C9H4ClF3N2/c10-8-6-3-5(9(11,12)13)1-2-7(6)14-4-15-8/h1-4H

Upstream product

• 16544-67-5 6-(trifluoromethyl)-3Η-quinazolin-4-one 
• 16544-67-5 6-(trifluoromethyl)quinazolin-4-ol 

Downstream Products

• 1005180-93-7 tert-butyl ((1R,3R,4S)-3-acetamido-4-((S)-2-oxo-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-1-yl)cyclohexyl)carbamate 
• 1005181-01-0 4-phenoxy-6-(trifluoromethyl)quinazoline 
• 1005181-45-2 tert-butyl (1R,3R,4S)-4-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)-3-propionamidocyclohexylcarbamate 
• 1005180-36-8 N-((1R,2S,5R)-5-(methylamino)-2-((S)-2-oxo-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-1-yl)cyclohexyl)acetamide 
• 1005180-67-5 N-(((1S,2S,5R)-5-methoxy-2-((3S)-2-oxo-3-((6-(trifluoromethyl)-4-quinazolinyl)amino)-1-pyrrolidinyl)cyclohexyl)methyl)acetamide 
• 845797-43-5 benzyl (2S,3S)-3-hydroxy-2-(2-(6-(trifluoromethyl)quinazolin-4-ylamino)acetamido)hex-4-ynylcarbamate 
• 847999-52-4 C₂₅H₃₄F₃N₅O₂ 
• 847999-46-6 C₂₄H₃₂F₃N₅O 

Relevant academic research and scientific papers

Stereoselective Bulk Synthesis of CCR2 Antagonist BMS-741672: Assembly of an All-cis (S,R,R)-1,2,4-Triaminocyclohexane (TACH) Core via Sequential Heterogeneous Asymmetric Hydrogenations

A concise bulk synthesis of stereochemically complex CCR2 antagonist BMS-741672 is reported. A distinct structural feature is the chiral all-cis 1,2,4-triaminocyclohexane (TACH) core, which was assembled through consecutive stereocontrolled heterogeneous

COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2

The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful

Cyclic derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

N-ALKYLATED DIAMINOPROPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of MCP-1 of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.