16544-67-5

Usage

Uses

Used in Pharmaceutical Industry:
6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE is used as a potential drug candidate for its diverse biological activities. The presence of the trifluoromethyl group contributes to its enhanced lipophilicity and metabolic stability, which are desirable properties for drug development.
Used in Anticancer Applications:
In the field of oncology, 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE is used as a potential anticancer agent. Its unique structure may allow it to target and inhibit specific cancer-related pathways, offering a new approach to cancer treatment.
Used in Antifungal Applications:
6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE is used as a potential antifungal agent, leveraging its ability to target and inhibit fungal growth, providing a new avenue for the treatment of fungal infections.
Used in Antiviral Applications:
In virology, 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE is used as a potential antiviral agent, with its unique properties allowing it to interfere with viral replication and infection processes.
Used in Central Nervous System Applications:
6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE is used in the study of its effects on the central nervous system, exploring its potential to treat neurological disorders or conditions related to the brain and spinal cord.
Overall, the diverse applications of 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE highlight its potential as a versatile compound in the field of medicinal chemistry and drug discovery, warranting further research and development.

InChI:InChI=1/C9H5F3N2O/c10-9(11,12)5-1-2-7-6(3-5)8(15)14-4-13-7/h1-4H,(H,13,14,15)

Upstream product

• 83265-53-6 2-amino-5-(trifluoromethyl)benzoic acid 
• 845797-42-4 2-amino-5-(trifluoromethyl)benzoic acid, hydrochloride 
• 3473-63-0 formamidine acetic acid 
• 1108668-05-8 2-amino-5-trifluoromethylbenzoic acid ethyl ester 
• 77287-34-4 formamide 

Downstream Products

• 16499-64-2 4-chloro-6-(trifluoromethyl)quinazoline 
• 1133219-38-1 3-⁽¹⁵⁾N-3-benzyl-6-(trifluoromethyl)quinazolin-4(3H)-one 
• 1133218-96-8 3-cyclohexyl-6-(trifluoromethyl)quinazolin-4(3H)-one 
• 1133218-93-5 C₁₅H₁₆F₃N₃ 
• 1133218-82-2 3-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexyl)-2-oxopyrrolidin-3-yl)-6-(trifluoromethyl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Visible-Light Photosynthesis of CHF2/CClF2/CBrF2-Substituted Ring-fused Quinazolinones in Dimethyl Carbonate

With eco-friendly and sustainable CO2-derived dimethyl carbonate as the sole solvent, the visible-light-induced cascade radical reactions have been established as a green and efficient tool for constructing various CHF2/CClF2/CBrF2-substituted ring-fused quinazolinones.

Synthesis, Anti-Tomato Spotted Wilt Virus Activities, and Interaction Mechanisms of Novel Dithioacetal Derivatives Containing a 4(3 H)-Quinazolinone Pyrimidine Ring

A series of unreported novel dithioacetal derivatives containing a 4(3H)-quinazolinone pyrimidine ring were synthesized, and their antiviral activities were evaluated against tomato spotted wilt virus (TSWV). A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was established, and compound D32 was designed and synthesized according to the analysis results of the CoMFA and CoMSIA models. The bioassay results showed that compound D32 exhibited excellent inactivation activity against TSWV, with EC50 values of 144 μg/mL, which was better than those of ningnanmycin (149 μg/mL) and the lead compound xiangcaoliusuobingmi (525 μg/mL). The binding ability of compound D32 to TSWV CP was tested by microscale thermophoresis (MST), and the binding constant value was 4.4 μM, which was better than those of ningnanmycin (6.2 μM) and xiangcaoliusuobingmi (59.1 μM). Therefore, this study indicates that novel dithioacetal derivatives containing a 4(3H)-quinazolinone pyrimidine ring may be applied as new antiviral agents.

Quinazolinone and isoquinolinone derivative

The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

IRAK INHIBITORS AND USES THEREOF

The present invention provides quinazoline and quinoline compounds, compositions thereof, and methods of using the same. Also disclosed is the activity of such compounds as inhibitors of IRAK enzymes.

Cyclic derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

N-ALKYLATED DIAMINOPROPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of MCP-1 of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

Quinazolin-4(3H)-one derivatives as anticoccidial agents

Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazolin-4-(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates therefor.