16501-77-2Relevant academic research and scientific papers
Syntheses and antitumor activities of N′1, N′3-dialkyl-N′1,N′3-di- (alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol
Chen, Shoujun,Sun, Lijun,Koya, Keizo,Tatsuta, Noriaki,Xia, Zhiqiang,Korbut, Timothy,Du, Zhenjian,Wu, Jim,Liang, Guiqing,Jiang, Jun,Ono, Mitsunori,Zhou, Dan,Sonderfan, Andrew
, p. 5070 - 5076 (2013/09/12)
A series of N′1,N′3-dialkyl- N′1,N′3-di(alkylcarbonothioyl) malonohydrazides have been designed and synthesized as anticancer agents by targeting oxidative stress and Hsp70 induction. Structure-activity relationship (SAR) studies lead to the discovery of STA-4783 (elesclomol), a novel small molecule that has been evaluated in a number of clinical trials as an anticancer agent in combination with Taxol.
A Convenient Synthesis of Alkyl and Aryl Substituted Bis-1,3,4-oxadiazoles
Al-Talib, Mahmoud,Tashtoush, Hasan,Odeh, Nedal
, p. 1811 - 1817 (2007/10/02)
Substituted bis-1,3,4-oxadiazoles 3a-l have been synthesized from the cyclization of N,N'-diaroyl or N,N'-dialkanoyl diacyl hydrazides, in presence of phosphorus oxychloride.All new compounds have been identified by 1H-NMR, 13C-NMR and elemental analysis.
Reference Data - Diacyl Acid Dihydrazides
Al-Talib, Mahmoud,Tashtoush, Hasan,Odeh, Nedal
, p. 1072 - 1075 (2007/10/02)
N,N'-Diacyl acid dihydrazides were prepared by the reaction of acid dihydrazides with two equivalents of acyl chlorides.The structure of these compounds were elucidated by 1H and 13C NMR spectroscopy.
