16503-47-2Relevant academic research and scientific papers
AMINOMETHYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 25, (2008/06/13)
The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is als
Privileged structure based ligands for melanocortin receptors - Substituted benzylic piperazine derivatives
Fisher, Matthew J.,Backer, Ryan T.,Collado, Ivan,De Frutos, Oscar,Husain, Saba,Hsiung, Hansen M.,Kuklish, Steve L.,Mateo, Ana I.,Mullaney, Jeffrey T.,Ornstein, Paul L.,Paredes, Cristina Garcia,O'Brian, Thomas P.,Richardson, Timothy I.,Shah, Jikesh,Zgombick, John M.,Briner, Karin
, p. 4973 - 4978 (2007/10/03)
Replacement of the aryl piperazine moiety in compound 1 with a variety of substituted benzylic piperazines (6) yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest
HOMOLYTIC ADDITION OF BENZYL BROMIDE TO UNSATURATED COMPOUNDS IN CONDITIONS OF METAL-COMPLEX INITIATION
Vasil'eva, T. T.,Gapusenko, S. I.,Vitt, S. V.,Terent'ev, A. B.
, p. 1841 - 1845 (2007/10/02)
Radical addition of benzyl bromide to unsaturated compounds containing substituents of a different polar nature, CH2=CHX (X = C4H9, SiMe3, CF3, CO2Me, CN, H), was conducted in the presence of the Fe(CO)5 + DMF (HMPA) system.Adducts were obtained and their structure was demonstrated by 13C NMR and mass spectrometry.Keywords: homolytic addition, benzyl bromide, unsaturated compounds, iron pentacarbonyl, DMF, HMPA.
