165035-65-4Relevant academic research and scientific papers
Chiral tridentate bis(oxazol-2-ylimino) isoindoline-based pincer ligands: isolation and characterizationviadeligation fromin situprepared Cd-ligand complexes
Baldauf, Lilia M.,Bernier, Lauren E.,Cryder, Jessica L.,Daley, Christopher J. A.,Fulton, Kayleen,Moore, Curtis E.,O'Toole, Maxwell,Reyes, Valeria,Rheingold, Arnold L.,Thomas, Theresa J.,Villase?or, Alexa,Zivkovic, Kristina
, p. 10041 - 10049 (2021)
The first isolation and structural characterization of a series of chiral trinitrogen 1,3-bis(4,5-dihydrooxazol-2-ylimino)isoindoline-based pincer ligands are reported. Cadmium complexes, isolated as Cd(L2X)2where L2X is t
Novel metal complexes containing a chiral trinitrogen isoindoline-based pincer ligand: In situ synthesis and structural characterization
Cryder, Jessica L.,Killgore, Andrew J.,Moore, Curtis,Golen, James A.,Rheingold, Arnold L.,Daley, Christopher J. A.
, p. 10671 - 10677 (2010)
The first synthesis and characterization of metal coordinated complexes containing in situ prepared chiral trinitrogen 1,3-bis(4,5-dihydrooxazol-2- ylimino)isoindoline-based pincer ligands are reported. Two zinc complexes, isolated as Zn(L)2, w
Designing chiral amido-oxazolines as new chelating ligands devoted to direct Cu-catalyzed oxidation of allylic C–H bonds in cyclic olefins
Samadi, Saadi,Jadidi, Khosrow,Samadi, Mojgan,Ashouri, Akram,Notash, Behrouz
, p. 862 - 867 (2019/01/08)
A new type of amido-oxazoline ligands was conveniently synthesized from inexpensive and commercially available materials in high yields and enantiomeric excesses. The corresponding chiral copper complexes with this class of ligands [C2 symmetric S,S-bis(amido-oxazoline-Cu(II) complex] were synthesized accordingly. The ORTEP diagram of ligand 6a and complex 6a-copper were compared and characterization of the complex confirmed the involvement of both dentate parts of the ligands, the oxygen and nitrogen atoms, in complexation with copper. The utilization of this amido-oxazoline ligands in the copper-catalyzed enantioselective esterification of allylic C–H bonds of cyclic olefins with tert-butyl-4-nitrobenzoperoxoate resulted in the highest activities, yields (up to 95%) and enantioselectivities (up to 96%) in the presence of HZSM-5 zeolite. These new findings highlight the protocol as one of the most attractive and useful methods for the oxidation of the asymmetric allylic C–H bond of cycloalkenes compared to other methodologies reported in the literature.
OXAZOLINE PSEUDODIMERS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
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Paragraph 0463, (2017/12/15)
The present disclosure is directed to oxazoline mono- and hetero-pseudodimer compounds, such as compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: These compounds are useful for treating pain. The present disclosure also relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of Formula (I) or (II) or a pharmaceutically acceptable salt or solvate thereof
Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
Galley, Guido,Beurier, Angélica,Décoret, Guillaume,Goergler, Annick,Hutter, Roman,Mohr, Susanne,P?hler, Axel,Schmid, Philipp,Türck, Dietrich,Unger, Robert,Zbinden, Katrin Groebke,Hoener, Marius C.,Norcross, Roger D.
supporting information, p. 192 - 197 (2016/03/01)
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound 1, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as 12 (RO5166017), 18 (RO5256390), 36 (RO5203648), and 48 (RO5263397). These compounds exhibit drug-like physicochemical properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction.
Development of bifunctional aza-bis(oxazoline) copper catalysts for enantioselective henry reaction
Lang, Kai,Park, Jongwoo,Hong, Sukwon
supporting information; experimental part, p. 6424 - 6435 (2010/12/19)
Base-functionalized aza-bis(oxazoline) ligands were prepared to explore the concept of dual activation through the Lewis acid and a tethered tertiary amine base. The catalytic activity of the Cu complex was evaluated for the asymmetric Henry reaction. Compared with a corresponding unfunctionalized copper complex with external 1-benzyl-4-ethylpiperazine base, the ethylpiperazine- functionalized aza-bis(oxazoline) copper catalyst resulted in rate acceleration (2.5 times) as well as improved enantioselectivity (72% ee vs 92% ee).
The role of binding constants in the efficiency of chiral catalysts immobilized by electrostatic interactions: The case of azabis(oxazoline)-copper complexes
Fraile, Jose M.,Garcia, Jose I.,Herrerias, Clara I.,Mayoral, Jose A.,Reiser, Oliver,Socuellamos, Antonio,Werner, Heiko
, p. 2997 - 3005 (2007/10/03)
As shown by theoretical calculations, azabis(oxazoline)-copper complexes are considerably more stable than the analogous bis(oxazoline)-copper complexes. This enhanced stability allows them to be efficiently immobilized by means of electrostatic interactions to different anionic supports, such as clays and nafion-silica nanocomposites, without the loss of a ligand, as is observed for bis(oxazolines). As a result, enantioselectivities of around 90% ee are obtained in the cyclopropanation reaction between styrene and ethyl diazoacetate. Moreover, the solid catalyst is easily recoverable.
