88026-82-8

Usage

Uses

Used in Pharmaceutical Synthesis:
(2S)-2-amino-2-phenylethan-1-ol hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals, including those targeting neurological and neurodegenerative disorders. Its chiral nature allows for the development of enantioselective drugs with improved efficacy and reduced side effects.
Used as a Chiral Auxiliary:
In the field of asymmetric synthesis, (2S)-2-amino-2-phenylethan-1-ol hydrochloride serves as a chiral auxiliary, aiding in the selective formation of desired enantiomers during chemical reactions. This application is crucial for the production of enantiomerically pure compounds, which is essential for the development of effective and safe medications.
Used in Organic Synthesis:
(2S)-2-amino-2-phenylethan-1-ol hydrochloride is utilized in various organic synthesis processes, contributing to the development of new compounds and materials with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
(2S)-2-amino-2-phenylethan-1-ol hydrochloride is also employed in research and development settings to study its potential applications and to develop new methods for its synthesis and use. This includes investigations into its potential therapeutic effects on neurological and neurodegenerative disorders, as well as its utility in the synthesis of novel compounds.

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 1426955-75-0 (R_S,S)-2-(1,1-dimethylethylsulfinamido)-2-phenylethyl pivalate 
• 1426955-76-1 (S)-2-phenyl-2-[(pivaloyloxy)methylsulfinamido]ethyl pivalate 

Downstream Products

• 20989-17-7 (2S)-2-phenylglycinol 
• 165035-65-4 (S)-2-amino-4-phenyl-4,5-dihydro-1,3-oxazole 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 116126-04-6 (-)-N-((S)-2-hydroxy-1-phenylethyl)benzamide 
• 1533409-58-3 (3S,10bR)-3,5-diphenyl-3,10b-dihydro-2H-oxazolo[2,3-a]isoquinoline 
• 1599446-42-0 (3S,11bR,Z)-5-benzylidene-3-phenyl-2,3,5,11b-tetrahydrooxazolo[3',2':1,5]pyrrolo[3,4-b]quinoline 
• 1599446-41-9 (3S,11bR,Z)-5-(4-methylbenzylidene)-3-phenyl-2,3,5,11b-tetrahydrooxazolo[3',2':1,5]pyrrolo[3,4-b]quinoline 

Relevant academic research and scientific papers

Intermolecular alkyl radical additions to enantiopure N-tert-butanesulfinyl aldimines

The sulfinyl group in (R)-N-tert-butanesulfinyl aldimines provides efficient control of the stereoselectivity in the intermolecular reactions with alkyl radicals. The methodology is applicable to aryl, heteroaryl, benzyl, and alkynyl imines, even those containing CN, CO2Me, COR, and OH groups. The best results are attained with hindered radicals (tertiary and secondary ones) without C=N bond reduction. This reaction complements the well-established organometallic additions to N-sulfinyl aldimines to obtain enantiomerically pure functionalized α-branched primary amines.

Stereoselectivity in the salt-cocrystal products formed by phenylglycinol or phenylglycine with their respective sodium or hydrochloride salts

The salt and stereoselective cocrystal phenomena associated with 2-phenylglycinol and 2-phenylglycine have been studied using X-ray powder diffraction and differential scanning calorimetry. The chiral identities of the free acids and their sodium salts, or the free bases and their chloride salts, were found to play a determining role as to whether a salt-cocrystal product could or could not be formed. In particular, when cocrystallization of an enantiomerically pure basic or zwitterionic substance with its enantiomerically pure acid addition salt was attempted, a salt-cocrystal was only obtained when the absolute configuration of the two reactants is opposite. On the other hand, it has been found that no stereoselectivity in salt-cocrystal formation existed in the cocrystallization of an enantiomerically pure acidic or zwitterionic substance with its enantiomerically pure base addition salt. Copyright