16507-61-2

Usage

Uses

Oleyl Chloride is used in preparation method of crosslinked polyethylene foam material.

Upstream product

• 143-28-2 oleoyl alcohol 
• 3386-33-2 1-chlorooctadecane 
• 79-37-8 oxalyl dichloride 
• 112-80-1 cis-Octadecenoic acid 
• 110-86-1 pyridine 
• 7719-09-7 thionyl chloride 
• 71-43-2 benzene 

Downstream Products

• 13127-82-7 N,N-bis(2-hydroxyethyl)oleylamine 
• 335193-67-4 3,6-Dioxatetracos-15(Z)-en-1-ol 
• 135391-28-5 (R,Z)-1-(2-(hydroxymethyl)pyrrolidin-1-yl)octadecan-9-en-1-one 
• 108455-80-7 (S,Z)-1-(2-(hydroxymethyl)pyrrolidin-1-yl)octadecan-9-en-1-one 
• 135391-19-4 (1R,2R)-2-(Oleoylamino)cyclohexanol 
• 135503-02-5 (1S,2S)-2-(Oleoylamino)cyclohexanol 
• 872-05-9 1-Decene 
• 1002-70-6 10-chloro-1-decene 
• 4084-07-5 1-tetradecene 
• 62706-15-4 14-chloro-tetradec-5-ene 
• 103512-22-7 4-octadec-9c-enyloxy-2-phenyl-2H-phthalazin-1-one 

Relevant academic research and scientific papers

COMPOSITIONS FOR TRANSFECTING mRNA INTO A CELL AND THEIR APPLICATIONS

The present invention relates to compositions for transfecting a messenger RNA (m RNA) into a cell and their applications. The present invention is directed to a composition for transfecting a mRNA into a cell comprising a mRNA, at least one neutral lipid and a cationic lipid of formula (I), wherein R1 R2, R3, R4 and R5, (CH2)n and A- are as defined in the description. The present invention also relates to uses of said composition and to a method for in vitro transfection of live cells.

CRYSTAL OF CYCLIC PHOSPHONIC ACID SODIUM SALT AND METHOD FOR MANUFACTURING SAME

An object of the present invention is to provide a crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and a method for producing the crystal. The present invention provides a crystal of a cyclic phosphonic acid sodium salt (2ccPA) represented by formula (1):

FUSOGENIC LIPOSOMES AND METHODS OF MAKING AND USING SAME

A liposome composition is provided which contains a liposome having: (i) an outermost lipid bilayer containing, in addition to a neutral, bilayer-preferring lipid, a fusion-promoting effective amount of an ionizable lipid having a protonatable, cationic headgroup and an unsaturated acyl chain; and (ii) a compartment adjacent to the outermost lipid bilayer which contains an aqueous solution having a first pH. External to the liposome in the composition is an aqueous solution having a second pH. The first pH is less than the pKa of the ionizable lipid in the outermost lipid bilayer and the second pH is greater than the pKa of the ionizable lipid in the outermost lipid bilayer, such that there is a pH gradient across the outermost lipid bilayer and the ionizable lipid is accumulated in the inner monolayer of the outermost lipid bilayer in response to the gradient. The liposome can be fused in a controlled manner to another lipid bilayer, for example, the plasma membrane of a mammalian cell, by degrading the pH gradient when fusion is to occur, such that the ionizable lipid is neutral, evenly distributed in the outermost lipid bilayer and, fusogenic. Controlled fusion can be used to control the delivery of a biologically active agent entrapped in the liposome into a cell.

Process for limiting the penetration into the skin and/or the keratinous fibres of an active cosmetic and/or pharmaceutical agent

A process, composition, and kit for limiting the penetration into the skin and/or the keratinous fibers of at least one cosmetically and/or pharmaceutically active agent present in a base cosmetic and/or pharmaceutical composition for topical application and in particular for reducing the rate of penetration into the skin and/or the keratinous fibers of the active agent(s). The process includes the joint use, with the base composition, of an effective amount of a dispersion of vesicles in a medium, the vesicles comprising at least one ceramide of formula (I): wherein R1 is chosen from saturated and unsaturated, linear and branched C1-C32 alkyl groups optionally substituted by at least one hydroxyl group, wherein said at least one hydroxyl group is optionally esterified by a group chosen from C1-C35 acyls; and R2 is chosen from saturated and unsaturated, linear and branched C1-C50 alkyl groups optionally substituted by at least one hydroxyl groups, and wherein said at least one hydroxyl group is optionally esterified by a group chosen from C1-C30 acyls.

Triphenylphosphine/2,3-dichloro-5,6-dicyanobenzoquinone as a new, selective and neutral system for the facile conversion of alcohols, thiols and selenols to alkyl halides in the presence of halide ions

A mixture of triphenylphosphine (Ph3P) and 2,3-dichloro-5,6-dicyanobenzoquinone in CH2Cl2 affords a complex which in the presence of R4NX (X=Cl, Br, I) converts alcohols, thiols and selenols into their corresponding alkyl halides in high yields at room temperature. The method is highly selective for the conversion of 1° alcohols in the presence of 2° ones and also 1° and 2° alcohols in the presence of 3° alcohols, thiols, epoxides, trimethylsilyl- and tetrahydropyranyl ethers, 1,3 dithianes, disulfides, and amides.

Substrate specificity of regiospecific desaturation of aliphatic compounds by a mutant Rhodococcus strain.

Substrate specificity of cis-desaturation of alipahtic compounds by resting cells of a mutant, Rhodococcus sp. strain KSM-MT66, was examined. Among substrates tested, the rhodococcal cells were able to convert n-alkanes (C13-C19), 1-chloroalkanes (C16 and C18), ethyl fatty acids (C14-C17) and alkyl (C1-C4) esters of palmitic acid to their corresponding unsaturated products of cis configuration. The products from n-alkanes and 1-chloroalkanes had a double bond mainly at the 9th carbon from their terminal methyl groups, and the products from acyl fatty acids had a double bond mainly at the 6th carbon from their carbonyl carbons.

Fusogenic lipsomes and methods for making and using same

A liposome composition is provided which contains a liposome having: (i) an outermost lipid bilayer containing, in addition to a neutral, bilayer preferring lipid, a fusion-promoting effective amount of an ionizable lipid having a protonatable, cationic headgroup and an unsaturated acyl chain; and (ii) a compartment adjacent to the outermost lipid bilayer which contains an aqueous solution having a first pH. External to the liposome in the composition is an aqueous solution having a second pH. The first pH is less than the pKa of the ionizable lipid in the outermost lipid bilayer and the second pH is greater than the pKa of the ionizable lipid in the outermost lipid bilayer, such that there is a pH gradient across the outermost lipid bilayer and the ionizable lipid is accumulated in the inner monolayer of the outermost lipid bilayer in response to the gradient. The liposome can be fused in a controlled manner to another lipid bilayer, for example, the plasma membrane of a mammalian cell, by degrading the pH gradient when fusion is to occur, such that the ionizable lipid is neutral, evenly distributed in the outermost lipid bilayer and, fusogenic. Controlled fusion can be used to control the delivery of a biologically active agent entrapped in the liposome into a cell.

A CONVENITENT PREPARATION OF ALKYL HALIDES AND CYANIDES FROM ALCOHOLS BY MODIFICATION OF THE MITSUNOBU PROSCEDURE

Alakanols are converted to the corresponding halides and cyanides with inversion of configuration by lithium salts in combination with a preformed complex of diethyl azodicarboxylate and triphenylphosphine.

N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof

Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. α-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriate tryptophan ester.

Process for preparing insect pheromones

The specification discloses a novel process for the preparation of 11-tetradecenal and novel intermediates therefor. There is also disclosed processes for the intermediates. The novel intermediates include 1,1-dialkoxy-9-halo-nonane and 1,1-dialkoxy-11-tetradecene. There is further disclosed a process for preparing a mixture of cis- and trans-11-tetradecenal at the molecular ratio of approximately 1-cis-form to 9 trans-form, by reacting a Grignard reagent of 1,1-dialkoxy-9-halo-nonane with a mixture (approximately 60:40) of 1-chloro-2-pentene and 3-chloro-1-pentene and thereafter hydrolyzing thus formed 1,1-dialkoxy-11-tetradecene. 11-Tetradecenal is useful as a sex pheromone against the female eastern spruce budworm (Choristoneura fumiferana). The 9:1 ratio of trans/cis isomers is believed to be the most effective ratio to use against the budworms.