16510-28-4

Upstream product

• 1046446-01-8 C₁₀H₁₁ClI₂ 
• 1046446-10-9 C₁₀H₁₁Br₂Cl 
• 6640-25-1 4-chlorophenyl cyclopropyl ketone 
• 40877-09-6 4-chloro-1-(4-chlorophenyl)butan-1-one 
• 108-90-7 chlorobenzene 
• 1065010-87-8 potassium cyclopropyltrifluoroborate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 1046446-14-3 C₁₀H₁₁Cl₃ 

Downstream Products

• 100-00-5 4-chlorobenzonitrile 

Relevant academic research and scientific papers

Method for preparing 4-cypro methylene phenylboronic acid

The invention discloses a method for preparing a 4-cypro methylene phenylboronic acid, and relates to the technical field of organic synthesis. The chlorobenzene is taken as the starting material, is subjected to a friedel-crafts reaction to generate 4-butanoyl chloride chlorobenzene, is subjected to a ring-closure reaction to generate 4-cypro formyl chlorobenzene, is subjected to a reduction reaction to generate 4-cypro methylene chlorobenzene, and is finally subjected to a Grignard boric acid reaction to generate the 4-cypro methylene phenylboronic acid. The cheap chlorobenzene, which is easy to get, is taken as the starting material, the preparation cost is remarkably lowered, the total molar yield of the product of 4-cypro methylene phenylboronic acid prepared through the 4-cypro methylene phenylboronic acid, the ring-closure reaction, the reduction reaction and the Grignard boric acid reaction is more than 35%, the production of the product is guaranteed on the basis of the low cost, and the method is suitable for industrial production.

Suzuki coupling of potassium cyclopropyl- and alkoxymethyltrifluoroborates with benzyl chlorides

Efficient Csp3-Csp3 Suzuki couplings have been developed with both potassium cyclopropyl- and alkoxymethyltrifluoroborates. Moderate to good yields have been achieved in the cross-coupling of potassium cyclopropyltrifluoroborate with benzyl chlorides possessing electron-donating or electron-withdrawing substituents. Benzyl chloride was also successfully cross-coupled to potassium alkoxymethyltrifluoroborates derived from primary, secondary, and tertiary alcohols.

Radical 3-exo-tet cyclization of 1,3-dihalopropanes with SmI2 to form cyclopropanes

The preparation of 1,1-disubstituted and monosubstituted cyclopropanes from corresponding 2,2-disubstituted and 2-monosubstituted 1,3-dihalopropanes, respectively, with SmI2 in THF was efficiently carried out. The reaction mechanism was propose