165252-27-7Relevant academic research and scientific papers
3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2
Penning, Thomas D.,Kramer, Steven W.,Lee, Len F.,Collins, Paul W.,Koboldt, Carol M.,Seibert, Karen,Veenhuizen, Amy W.,Zhang, Yan Y.,Isakson, Peter C.
, p. 2121 - 2124 (1997)
A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.
1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
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, (2008/06/13)
A class of 1,4,5-triphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula II STR1 wherein R1 is selected from the group hydr
1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
-
, (2008/06/13)
A class of 1,4,5-triphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I STR1 wherein R1 is one or more groups independen
