175676-93-4Relevant academic research and scientific papers
3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2
Penning, Thomas D.,Kramer, Steven W.,Lee, Len F.,Collins, Paul W.,Koboldt, Carol M.,Seibert, Karen,Veenhuizen, Amy W.,Zhang, Yan Y.,Isakson, Peter C.
, p. 2121 - 2124 (2007/10/03)
A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.
