Bioorganic and Medicinal Chemistry Letters p. 2121 - 2124 (1997)
Update date:2022-07-30
Topics:
Penning, Thomas D.
Kramer, Steven W.
Lee, Len F.
Collins, Paul W.
Koboldt, Carol M.
Seibert, Karen
Veenhuizen, Amy W.
Zhang, Yan Y.
Isakson, Peter C.
A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.
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