165258-70-8 Usage
Description
2-AMINO-4-DIMETHYLAMINO-6-FLUOROPYRIMIDINE, also known as Leflunomide, is a chemical compound that functions as an immunomodulatory and anti-inflammatory medication. It is recognized for its ability to suppress the immune system and reduce inflammation, particularly in the joints.
Uses
Used in Pharmaceutical Industry:
2-AMINO-4-DIMETHYLAMINO-6-FLUOROPYRIMIDINE is used as an immunosuppressive and anti-inflammatory agent for the treatment of rheumatoid arthritis. It operates by inhibiting dihydroorotate dehydrogenase, a key enzyme in the synthesis of DNA and RNA in rapidly dividing cells like those in the immune system, thereby managing the symptoms and progression of the disease.
Additionally, it is used as a potential therapeutic agent for other autoimmune diseases and certain types of cancer due to its immunomodulatory effects. The medication is available in various forms, such as tablets, and can be administered alone or in combination with other drugs to enhance the management of rheumatoid arthritis and explore its efficacy in other medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 165258-70-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,2,5 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 165258-70:
(8*1)+(7*6)+(6*5)+(5*2)+(4*5)+(3*8)+(2*7)+(1*0)=148
148 % 10 = 8
So 165258-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H9FN4/c1-11(2)5-3-4(7)9-6(8)10-5/h3H,1-2H3,(H2,8,9,10)
165258-70-8Relevant articles and documents
Synthesis and Properties of 2,4-Disubstituted 6-Fluoropyrimidines
Popova,Studentsov
, p. 1376 - 1381 (2007/10/03)
Reaction of 2,4,6-trifluoropyrimidine and 2- and 4-aminodifluoropyrimidines with various amines in DMF is studied. As a result, a series of new 2,4-diamino-substituted 6-fluoropyrimidines with similar or different amino substituents are synthesized.
