675-11-6

Basic information

• Product Name: 2-AMINO-4,6-DIFLUOROPYRIMIDINE
• Synonyms: 2-AMINO-4,6-DIFLUOROPYRIMIDINE;4,6-DIFLUOROPYRIMIDIN-2-YLAMINE;4,6-DIFLUORO-2-PYRIMIDINAMINE;2-Pyrimidinamine, 4,6-difluoro-;2-Pyrimidinamine, 4,6-difluoro- (9CI);4,6-DifluoropyriMidin-2-aMine
• CAS NO: 675-11-6
• Molecular Formula: C₄H₃F₂N₃
• Molecular Weight: 131.08
• Product Categories: PYRIMIDINE;Heterocyclic Compounds
• Mol File: 675-11-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 214-216 °C
• Boiling Point: 270.7oC at 760 mmHg
• Flash Point: 117.5oC
• Appearance: /
• Density: 1.513g/cm3
• Vapor Pressure: 0.00672mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.68±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4,6-DIFLUOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4,6-DIFLUOROPYRIMIDINE(675-11-6)
• EPA Substance Registry System: 2-AMINO-4,6-DIFLUOROPYRIMIDINE(675-11-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 675-11-6(Hazardous Substances Data)

Usage

Uses

4,6-Difluoropyrimidin-2-amine is a useful research chemical.

InChI:InChI=1/C4H3F2N3/c5-2-1-3(6)9-4(7)8-2/h1H,(H2,7,8,9)

Upstream product

• 696-82-2 2,4,6-trifluoropyrimidine 

Downstream Products

• 165258-68-4 2-amino-4-ethylamino-6-fluoropyrimidine 
• 2253-05-6 2-amino-6-fluoro-3H-pyrimidin-4-one 
• 165258-66-2 2-amino-4-methylamino-6-fluoropyrimidine 
• 165258-72-0 2-amino-4-diethylamino-6-fluoropyrimidine 
• 165258-71-9 4-amino-2-dimethylamino-6-fluoropyrimidine 
• 165258-70-8 2-amino-4-dimethylamino-6-fluoropyrimidine 

Relevant articles and documents

2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles

In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.