675-11-6

Usage

Uses

4,6-Difluoropyrimidin-2-amine is a useful research chemical.

InChI:InChI=1/C4H3F2N3/c5-2-1-3(6)9-4(7)8-2/h1H,(H2,7,8,9)

Upstream product

• 696-82-2 2,4,6-trifluoropyrimidine 

Downstream Products

• 165258-70-8 2-amino-4-dimethylamino-6-fluoropyrimidine 
• 165258-71-9 4-amino-2-dimethylamino-6-fluoropyrimidine 
• 165258-72-0 2-amino-4-diethylamino-6-fluoropyrimidine 
• 165258-66-2 2-amino-4-methylamino-6-fluoropyrimidine 
• 2253-05-6 2-amino-6-fluoro-3H-pyrimidin-4-one 
• 165258-68-4 2-amino-4-ethylamino-6-fluoropyrimidine 

Relevant academic research and scientific papers

2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles

In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.

MECHANISMS FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 6. INVESTIGATIONS INTO THE ACTIVATING EFFECT OF ORTHO-FLUORINE IN NUCLEOPHILIC AROMATIC SUBSTITUTION

Separate activating effects for ortho- and meta- fluorine, on nucleophilic aromatic substitution, are determinated for pyrimidine and pyridine systems.Comparisons confirm the importance of ion-dipole interactions for activation by ortho-fluorine.The effects of ortho-fluorine on anionic ?-complexes are also discussed.