165263-40-1Relevant academic research and scientific papers
An investigation into the structure-activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol
Beattie, David,Beer, David,Bradley, Michelle E.,Bruce, Ian,Charlton, Steven J.,Cuenoud, Bernard M.,Fairhurst, Robin A.,Farr, David,Fozard, John R.,Janus, Diana,Rosethorne, Elizabeth M.,Sandham, David A.,Sykes, David A.,Trifilieff, Alexandre,Turner, Katharine L.,Wissler, Elke
, p. 6280 - 6285 (2012/10/30)
The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is described. Evaluation of the affinity of these analogues for the β2-adrenoceptor identified t
QUINOLINE-2-ONE-DERIVATIVES FOR THE TREATMENT OF AIRWAYS DISEASES
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Page/Page column 37-38, (2008/06/13)
Compounds of formula (I) in free or salt form, wherein -C-Y-, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the (β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
Synthesis of quaternary alkylammonium sulfobetaines
Ward, Robert S.,Davies, Joanna,Hodges, Geoffrey,Roberts, David W.
, p. 2431 - 2439 (2007/10/03)
A series of quaternary alkylammonium sulfobetaines of general formula RN+(CH3)2(CH2)nSO 3-, where n = 2-4, have been synthesised by reacting the corresponding N,N-dimethylamines with either sodium 2-chloroethanesulfonate (n = 2), 1,3-propane-sultone (n = 3), or 1,4-butanesultone (n = 4). Full details of the preparation of the required N,N-dimethylamines are reported.
SCHWEFELVERBINDUNGEN DES ERDOELS XXII. ALKYL-10,11-DIHYDRODIINDENOTHIOPHENE
Boberg, Friedrich,Deters, Karin,Schulz, Juergen,Torges, Karl-Franz
, p. 69 - 80 (2007/10/03)
The one-pot syntheses of alkyl-10,11-dihydrodiindenothiophenes (3) by bromination and sulfurization of alkylindan-1-ones without substituents at C-2 (1) has been studied with 14 1 with C1-C4-rests at the benzene and or the cyclopentane ring. 9 dialkyl-3 and 3 tetraalkyl-3 are prepared in yields of 7-66percent; an octamethyl-3 is detected by tlc and ms. 2 dialkyl-3 are prepared too by an independent syntheses from dimethyl 2,5-bis(methylphenyl)thiophene-3,4-dicarboxylates (13).The mechanism of the one-pot syntheses, which gives diindeno-1,4-dithiines too,is discussed.The oxidation of 4 3 has been studied.Key words: Alkylindan-1-ones, alkyl-10,11-dihydrodiindenothiophenes, alkyldiindeno-1,4-dithiines, one-pot syntheses of anellated thiophenes, oxidation of anellated thiophenes.
