16527-24-5

Basic information

• Product Name: N-(2,3-dihydroxypropyl)acetamide
• Synonyms: 3-acetamido-1,2-propanediol; acetamide, N-(2,3-dihydroxypropyl)-; N-(2,3-Dihydroxypropyl)acetamide
• CAS NO: 16527-24-5
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.1457
• Mol File: 16527-24-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 430.745°C at 760 mmHg
• Flash Point: 214.307°C
• Density: 1.185g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.479
• CAS DataBase Reference: N-(2,3-dihydroxypropyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dihydroxypropyl)acetamide(16527-24-5)
• EPA Substance Registry System: N-(2,3-dihydroxypropyl)acetamide(16527-24-5)

Safety Data

• Hazardous Substances Data: 16527-24-5(Hazardous Substances Data)

Upstream product

• 616-30-8 3-Amino-1,2-propanediol 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 108587-48-0 N-(2-Hydroxy-3-trityloxy-propyl)-acetamide 
• 108587-49-1 Hexadecanoic acid 1-(acetylamino-methyl)-2-trityloxy-ethyl ester 
• 108587-51-5 N-(2-Hexadecyloxy-3-trityloxy-propyl)-acetamide 

Relevant articles and documents

Enzymatic Resolutions in 3-amino-1,2-propanediol series

The resolution of 3-amino-1,2-propanediol derivatives has been carried out by way of enzymatic catalysed hydrolyses or acylations.S substrates are preferentally attacked, and hydrolysis of the diisobutyrate derivative with E.30000 lipase gave the best enantioselectivity.

Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines

Paracellular permeability enhancers have been used to improve the oral bioavailability of hydrophilic drugs; however, the mechanism of action of many enhancers is poorly understood. In this study, highly potent enhancers of paracellular permeability were

N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors

Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding N-hydroxyl compounds exhibited weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability under the oxidation by horseradish peroxidase in the presence of H2O2. These compounds also displayed vasodilatory activity. Elsevier Science Ltd. All rights reserved.