16529-06-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(1H-Benzimidazol-2-yl) Benzoic Acid is used as a pharmaceutical candidate for its potential anti-inflammatory and anti-tumor activities. Its unique characteristics and presence of the benzimidazole group make it a promising target for the development of new drugs with therapeutic applications.
Used in Medicinal Chemistry Research:
2-(1H-Benzimidazol-2-yl) Benzoic Acid is used as a subject of research in medicinal chemistry to explore its potential biological and pharmacological properties. 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID's unique characteristics and presence of the benzimidazole group make it an interesting target for further investigation and development in the field.

InChI:InChI=1/C14H10N2O2/c17-14(18)10-6-2-1-5-9(10)13-15-11-7-3-4-8-12(11)16-13/h1-8H,(H,15,16)(H,17,18)

Upstream product

• 85-44-9 phthalic anhydride 
• 95-54-5 1,2-diamino-benzene 
• 34442-94-9 N-(o-nitrophenyl)phthalimide 
• 858442-03-2 [2-(2-amino-phenyl)-4-oxo-1,2,3,4-tetrahydro-phthalazin-1-yl]-acetic acid 
• 64-17-5 ethanol 
• 119-67-5 o-carboxybenzaldehyde 
• 1780-94-5 2-(2'-imidazolyl)benzoic acid 
• 4506-62-1 N-(2-aminophenyl)phthalimide 
• 7297-65-6 2-((2-aminophenylamino)carbonyl) benzoic acid 
• 64-19-7 acetic acid 
• 248-72-6 11H-benzo[4,5]imidazo[2,1-a]isoindole 
• 7647-01-0 hydrogenchloride 
• 88-95-9 Phthaloyl dichloride 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 939409-06-0 2-(1H-benzimidazol-2-yl)-benzoic acid ethyl ester 
• 1148018-34-1 C₂₀H₁₃N₃O₃ 
• 2717-05-7 1,2-benzoylenebenzimidazole 
• 716-79-0 2-phenyl-1H-benzoimidazole 

Relevant academic research and scientific papers

Cu(OAc)2-Mediated benzimidazole-directed C-H cyanation using 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source

A new protocol for the Cu(OAc)2-mediated cyanation of arenes using benzimidazole as the directing group with 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source was developed. A series of cyano derivatives were facilely and conveniently obtained in moderate to good yields by using this method. The C-H activation catalytic system was originally applied to the C(sp2)-H cyanation of the aryl/heteroaryl to synthesize 2-(1H-benzo[d]imidazol-2-yl)aryl nitriles. There were 19 new compounds in the synthesized 20 cyanide products. In this reaction, 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source was originally employed in the C(sp2)-H cyanation of the arenes. In addition, a fluorescent material 5a was obtained by derivative reactions of the obtained cyanide product 3.

Synthesis and characterization of bis[2-(1H-Benzimidazol-2-yl)benzoato] nickel(II), and its use for preparation of dimethyl carbonate from methanol and CO2

A new complex, bis[2-(1H-benzimidazol-2-yl)benzoato]nickel(II) (NiL 2), has been synthesized and characterized. It was used as catalyst for synthesis of dimethyl carbonate (DMC) from methanol and CO2 in the presence of dicyclohexyl c

Wavelength dependent photoextrusion and tandem photo-extrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides

Ninhydrin bis-acetals give access to 8-ring lactones, benzocyclo-butenes and spirocyclic orthoanhydrides through photoextrusion and tandem photoextrusion reactions. Syntheses of fimbricalyxlactone B, isoshihunine and numerous biologically-relevant heteroc

Composition based on benzimidazole carboxylic acid compound and application thereof

The invention belongs to the field of medicine and pharmacology, and particularly relates to a pharmaceutical composition taking benzimidazole carboxylic acid and pharmaceutically acceptable salt thereof as active ingredients. The pharmaceutical composition taking the benzimidazole carboxylic acid and pharmaceutically acceptable salt thereof as main active ingredients is used for preventing and/ortreating respiratory tract reaction and nasal congestion caused by allergic reaction, nasal congestion caused by other reasons and other symptoms, and can realize immediate and/or lasting alleviationof congestion. The invention also provides a method of treating and/or alleviating and/or preventing nasal congestion in a patient, the method comprising administering to a patient in need thereof aneffective amount of the pharmaceutical composition of the benzimidazole carboxylic acid or a pharmaceutically acceptable salt thereof.

SYNTHESIS METHOD OF IMIDAZOLES

PROBLEM TO BE SOLVED: To provide benzimidazoles with small number of processes at high selectivity and high purity. SOLUTION: A synthesis method of benzimidazoles synthesizes at least one of an imidazole derivative and a carboxy imidazole derivative by reacting a diamine derivative and at least one of a dicarboxylic acid derivative and a dicarboxylic acid anhydride derivative in subcritical water or in supercritical water. For example, in subcritical water or in supercritical water, by reacting o-phenylene diamine and at least one of phthalic acid and phthalic anhydride, 2-phenylbenzimidazole and 2-o-benzimidazole benzoate are synthesized. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

2-benzimidazolyl benzoic acid copper complex with anti-fungal activity and preparation method

The invention discloses a 2-benzimidazolyl benzoic acid copper complex with anti-fungal activity and a preparation method. The complex is prepared by the following steps: taking 2-benzimidazolyl benzoic acid and Cu(NO3)2.3H2O to react in a mixed solvent o

An efficiently cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives

A highly efficient cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives under one atmosphere pressure is reported. This methodology represents a useful extension of benzimidazole used as ligand in metal catalysis, and the catalytic mechanism has been proved by computer simulation. Notably, this new cobalt precatalyst, which promotes the carbonylation reaction dramatically and has already been used for scale-up experiment of phenylacetic acid derivatives.

Substituted 2-formylbenzoic acids in the synthesis of 11H-isoindolo[2,1-a] benzimidazol-11-ones, 5H-isoindolo[2,1-a][3,1]benzoxazine-5,11(6aH)-diones, and 6,6a-dihydroisoindolo-[2,1-a]quinazoline-5,11-diones

Optimal conditions were developed for the synthesis of 11H-isoindolo[2,1-a] benzimidazol-11-one, 5H-isoindolo[2,1-a][3,1]benzoxazine-5,11(6aH)-dione, and 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives in the reaction of substituted 2-formylbenzoic acids with o-phenylenediamine, anthranilic acid, and anthranilamide, respectively. The bifolded structure of 6,6a- dihydroisoindolo-[1,2-a]quinazoline-5,11-dione was verified and investigated.

A new laccase-catalyzed domino process and its application to the efficient synthesis of 2-aryl-1H-benzimidazoles

The laccase-catalyzed domino reaction of o-phenylenediamine and benzaldehydes with aerial oxygen as the oxidant exclusively yields 2-aryl-1H-benzimidazoles in good to very good yields. It is easy to perform under very mild reaction conditions.

Green synthesis of polycyclic benzimidazole derivatives and organic semiconductors

Polycyclic benzimidazole derivatives, an important class of compounds in organic electronics and photovoltaics, were prepared using a solvent-free "green" process based on heating carboxylic acid anhydrides and arylene diamines in the presence of zinc acetate in the solid state. Products were isolated and purified directly by train sublimation of the crude reaction mixtures. The reaction conditions were optimized using various carboxylic acid anhydrides. Optical and electrochemical properties of these materials are also described.