16529-06-9

Basic information

• Product Name: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID
• Synonyms: 2-(1H-BENZOIMIDAZOL-2-YL)BENZOIC ACID;2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID;2-(2-CARBOXYPHENYL)BENZIMIDAZOLE;2-(1H-Benzo[d]iMidazol-2-yl)benzoic acid
• CAS NO: 16529-06-9
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.24
• Mol File: 16529-06-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 513.2°Cat760mmHg
• Flash Point: 264.2°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 2.34E-11mmHg at 25°C
• Refractive Index: 1.717
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID(16529-06-9)
• EPA Substance Registry System: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID(16529-06-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 16529-06-9(Hazardous Substances Data)

Usage

Description

2-(1H-Benzimidazol-2-yl) Benzoic Acid is a chemical compound with the molecular formula C14H10N2O2, belonging to the class of benzoic acids and a derivative of benzimidazole. It is characterized by the presence of a benzimidazole group, which endows the molecule with unique properties and makes it a promising target for research and development in medicinal chemistry. 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID has been studied for its potential biological and pharmacological properties, including anti-inflammatory and anti-tumor activities, and is being investigated for its use in the development of new drugs with therapeutic applications.

Uses

Used in Pharmaceutical Industry:
2-(1H-Benzimidazol-2-yl) Benzoic Acid is used as a pharmaceutical candidate for its potential anti-inflammatory and anti-tumor activities. Its unique characteristics and presence of the benzimidazole group make it a promising target for the development of new drugs with therapeutic applications.
Used in Medicinal Chemistry Research:
2-(1H-Benzimidazol-2-yl) Benzoic Acid is used as a subject of research in medicinal chemistry to explore its potential biological and pharmacological properties. 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID's unique characteristics and presence of the benzimidazole group make it an interesting target for further investigation and development in the field.

InChI:InChI=1/C14H10N2O2/c17-14(18)10-6-2-1-5-9(10)13-15-11-7-3-4-8-12(11)16-13/h1-8H,(H,15,16)(H,17,18)

Upstream product

• 64-17-5 ethanol 
• 95-54-5 1,2-diamino-benzene 
• 119-67-5 o-carboxybenzaldehyde 
• 4506-62-1 N-(2-aminophenyl)phthalimide 
• 2835-58-7 2-aminoazobenzene 
• 34442-94-9 N-(o-nitrophenyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 485-47-2 indan-1,2,3-trione hydrate 
• 197173-07-2 1,3-bis(ethylenedioxy)-2-indanone 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 2717-05-7 1,2-benzoylenebenzimidazole 
• 51-17-2 benzoimidazole 
• 118-92-3 anthranilic acid 
• 39145-59-0 o-phenylenediamine hydrochloride 

Downstream Products

• 939409-06-0 2-(1H-benzimidazol-2-yl)-benzoic acid ethyl ester 
• 1148018-34-1 C₂₀H₁₃N₃O₃ 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 2717-05-7 1,2-benzoylenebenzimidazole 

Relevant articles and documents

Cu(OAc)2-Mediated benzimidazole-directed C-H cyanation using 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source

A new protocol for the Cu(OAc)2-mediated cyanation of arenes using benzimidazole as the directing group with 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source was developed. A series of cyano derivatives were facilely and conveniently obtained in moderate to good yields by using this method. The C-H activation catalytic system was originally applied to the C(sp2)-H cyanation of the aryl/heteroaryl to synthesize 2-(1H-benzo[d]imidazol-2-yl)aryl nitriles. There were 19 new compounds in the synthesized 20 cyanide products. In this reaction, 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source was originally employed in the C(sp2)-H cyanation of the arenes. In addition, a fluorescent material 5a was obtained by derivative reactions of the obtained cyanide product 3.

Wavelength dependent photoextrusion and tandem photo-extrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides

Ninhydrin bis-acetals give access to 8-ring lactones, benzocyclo-butenes and spirocyclic orthoanhydrides through photoextrusion and tandem photoextrusion reactions. Syntheses of fimbricalyxlactone B, isoshihunine and numerous biologically-relevant heteroc

SYNTHESIS METHOD OF IMIDAZOLES

PROBLEM TO BE SOLVED: To provide benzimidazoles with small number of processes at high selectivity and high purity. SOLUTION: A synthesis method of benzimidazoles synthesizes at least one of an imidazole derivative and a carboxy imidazole derivative by reacting a diamine derivative and at least one of a dicarboxylic acid derivative and a dicarboxylic acid anhydride derivative in subcritical water or in supercritical water. For example, in subcritical water or in supercritical water, by reacting o-phenylene diamine and at least one of phthalic acid and phthalic anhydride, 2-phenylbenzimidazole and 2-o-benzimidazole benzoate are synthesized. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT