1653-35-6Relevant academic research and scientific papers
Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles
Sugandhi, Eko W.,Falkinham III, Joseph O.,Gandour, Richard D.
, p. 3842 - 3853 (2007)
Two series of water-soluble, symmetrical two-tailed homologous dendritic amphiphiles-R2NCONHC((CH2)2COOH)3, 2(n,n), and R2CHNHCONHC((CH2)2COOH)3, 3(n,n), where R = n-CnH2n+1-were synthesized and compared to R″NHCONHC((CH2)2COOH)3, 1(n), R″ = n-CnH2n+1, to determine whether antimicrobial activity was influenced by total or individual alkyl chain lengths, and whether antimicrobial activity depends on hydrophobicity or tail topology (one or two). In a broad screen of 11 microorganisms, 2(n,n) and 3(n,n) generally displayed higher minimal inhibitory concentrations (MICs) than 1(n) against growth as measured by broth microdilution assays. Chain-length specificity was observed against Candida albicans as 1(16), 2(8,8), and 3(8,8) showed the lowest MIC in their respective series. The one case where two-tailed compounds displayed the lowest MICs-3(10,10), 15 μM; 3(11,11), 7.2 μM; and 3(12,12), 6.9 μM-was against Cryptococcus neoformans.
COMPOUNDS USEFUL IN HIV THERAPY
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Page/Page column 101-102; 131, (2021/10/02)
The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.
LIPID NANOPARTICLE COMPOSITION
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Paragraph 00491, (2021/10/15)
Provided herein are lipids that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination.
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
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, (2018/07/04)
What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
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, (2018/07/05)
What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons;R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons;L1 and L2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons;X1 is S or O;R3 is a linear or branched alkylene consisting of 1 to 6 carbons; andR4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
Synthesis and characterization of mesogenic triphenylene-perylene dyads with phenoxy-alkoxy linkers
Kong, Xiangfei,Dai, Shengping,Wang, Guixia,Zhang, Zhouyang,Zhang, Laiqi,Liao, Peihai,Liu, Wenting
, p. 56 - 64 (2017/09/07)
Three novel triphenylene-perylene dyads with phenoxy-alkoxy linkers (PDI-OPhO-Cn-O- TP6, n = 6, 8, 10) have been synthesized and characterized by FT-IR, MS, 13C, and 1H NMR. The mesomorphic properties of these compounds were investigated by polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). It was found that the dyads (PDI-OPhO-Cn-O-TP6, n = 6, 8) only showed thermotropic columnar mesophase in the heating process, while the dyad (PDI-OPhO-C10-O-TP6) showed enantiotropic columnar mesophase in both heating and cooling processes.
Triphenylene-flexible bridge-perylene diimide binary compound and preparation method and application thereof
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Paragraph 0079; 0080; 0081, (2017/01/02)
The invention discloses a triphenylene-flexible bridge-perylene diimide binary compound and a preparation method thereof and application of the compound serving as an organic solar cell active layer. Compared with the prior art, the triphenylene-flexible bridge-perylene diimide binary compound has the advantage of easily adjusting the liquid crystalline phase transformation temperature and temperature interval, and the compound has the application in photology, electrooptics and electronics, and particularly has the application in serving as the organic solar cell active layer. Please see the formula in the description.
LPA RECEPTOR AGONISTS AND ANTAGONISTS
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Page/Page column 51, (2010/05/14)
Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
Highly efficient deacetylation by use of the neutral organotin catalyst [tBu2SnOH(Cl)]2
Orita, Akihiro,Hamada, Yuuki,Nakano, Takehiko,Toyoshima, Shinji,Otera, Junzo
, p. 3321 - 3327 (2007/10/03)
Deprotection of acetyl esters is effected cleanly by the neutral organotin catalyst, [tBu2SnOH(Cl)]2. The mildness of the reaction gives rise to great synthetic versatility and in the process a variety of functional groups are tolerated. Differentiations between primary, secondary, and tertiary alcohols and between acetyl ester and other esters are feasible. No racemization occurs with chiral acetyl esters. Exclusive deprotection of primary acetyl esters in carbohydrates and nucleosides is observed. The crude product thus obtained can be used for further reactions without purification.
Highly powerful and practical acylation of alcohols with acid anhydride catalyzed by Bi(OTf)3
Orita,Tanahashi,Kakuda,Otera
, p. 8926 - 8934 (2007/10/03)
Bi(OTf)3-catalyzed acylation of alcohols with acid anhydride was evaluated in comparison with other acylation methods. The Bi(OTf)3/acid anhydride protocol was so powerful that sterically demanding or tertiary alcohols could be acylated smoothly. Less reactive acylation reagents such as benzoic and pivalic anhydride are also activated by this catalysis. In these cases, a new technology was developed in order to overcome difficulty in separation of the acylated product from the remaining acylating reagent: methanolysis of the unreacted anhydride into easily separable methyl ester realized quite easy separation of the desired acylation product. The Bi(OTf)3/acid anhydride protocol was applicable to a wide spectrum of alcohols bearing various functionalities. Acid-labile THP- or TBS-protected alcohol, furfuryl alcohol, and geraniol could be acylated as well as base-labile alcohols. Even acylation of functionalized tertiary alcohols was effected at room temperature.
