1653-35-6Relevant articles and documents
Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles
Sugandhi, Eko W.,Falkinham III, Joseph O.,Gandour, Richard D.
, p. 3842 - 3853 (2007)
Two series of water-soluble, symmetrical two-tailed homologous dendritic amphiphiles-R2NCONHC((CH2)2COOH)3, 2(n,n), and R2CHNHCONHC((CH2)2COOH)3, 3(n,n), where R = n-CnH2n+1-were synthesized and compared to R″NHCONHC((CH2)2COOH)3, 1(n), R″ = n-CnH2n+1, to determine whether antimicrobial activity was influenced by total or individual alkyl chain lengths, and whether antimicrobial activity depends on hydrophobicity or tail topology (one or two). In a broad screen of 11 microorganisms, 2(n,n) and 3(n,n) generally displayed higher minimal inhibitory concentrations (MICs) than 1(n) against growth as measured by broth microdilution assays. Chain-length specificity was observed against Candida albicans as 1(16), 2(8,8), and 3(8,8) showed the lowest MIC in their respective series. The one case where two-tailed compounds displayed the lowest MICs-3(10,10), 15 μM; 3(11,11), 7.2 μM; and 3(12,12), 6.9 μM-was against Cryptococcus neoformans.
COMPOUNDS USEFUL IN HIV THERAPY
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Page/Page column 101-102; 131, (2021/10/02)
The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
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, (2018/07/04)
What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
Synthesis and characterization of mesogenic triphenylene-perylene dyads with phenoxy-alkoxy linkers
Kong, Xiangfei,Dai, Shengping,Wang, Guixia,Zhang, Zhouyang,Zhang, Laiqi,Liao, Peihai,Liu, Wenting
, p. 56 - 64 (2017/09/07)
Three novel triphenylene-perylene dyads with phenoxy-alkoxy linkers (PDI-OPhO-Cn-O- TP6, n = 6, 8, 10) have been synthesized and characterized by FT-IR, MS, 13C, and 1H NMR. The mesomorphic properties of these compounds were investigated by polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). It was found that the dyads (PDI-OPhO-Cn-O-TP6, n = 6, 8) only showed thermotropic columnar mesophase in the heating process, while the dyad (PDI-OPhO-C10-O-TP6) showed enantiotropic columnar mesophase in both heating and cooling processes.