1653-68-5

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 100-19-6 (4-nitrophenyl)ethanone 
• 100-47-0 benzonitrile 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 83266-97-1 4-(4'-aminophenyl)-2,6-bis(4''-aminophenyl)pyridine 

Relevant academic research and scientific papers

Three-component one-pot synthesis of 2,4,6-triarylpyridines without catalyst and solvent

An efficient and green synthesis of 2,4,6-triarylpyridines by a one-pot three-component condensation of aromatic aldehydes, substituted acetophenones, and ammonium acetate without catalyst at 130°C under solvent-free conditions is described. This method offers several advantages such as simple procedure, easy work-up, short reaction time, low cost, environmentally friendly conditions, and moderate to high yields.

An efficient synthesis of 2,4,6-triarylpyridines via solvent-free reaction between acetophenoneoximes and aldehydes

An efficient synthesis of 2,4,6-triarylpyridines is described. Heating a mixture of an acetophenoneoxime and an aldehyde under solvent-free conditions afforded Kr?hnke pyridines in excellent yields. In this method acetophenoneoximes are directly used for the preparation of Kr?hnke pyridines under metal-free conditions. Georg Thieme Verlag Stuttgart New York.

Synthesis of Di- and triazido derivatives of 2,4,6-Triphenylpyridine

The possibility of obtaining new di- and triazidophenylpyridines: 4-phenyl-2,6-bis(4-azidophenyl) pyridine and 2,4,6-tris(4-azidophenyl)pyridine by a three-stage synthesis from commercially available compounds was studied. Pleiades Publishing, Ltd., 2010.

Kr?hnke reaction in aqueous media: one-pot clean synthesis of 4′-aryl-2,2′:6′,2″-terpyridines

A clean aqueous Kr?hnke reaction process has been accomplished via a one-pot procedure of 2-acetylpyridine with aromatic aldehyde and ammonium acetate under microwave irradiation or conventional heating conditions. This method is convenient, economic and environmental friendly.