Synthesis of oligodeoxynucleotides containing 4'-C-(hydroxymethyl)thymidine: Novel promising antisense molecules

DOI: 10.1016/0040-4039(95)00301-R

Source and publish data:

Tetrahedron Letters p. 2535 - 2538 (1995)

Update date:2022-08-04

Topics:

Authors:

Fensholdt

Thrane Thrane

Wengel Wengel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)00301-R

4'-C-(Hydroxymethyl)thymidine derivative 1 was transformed into phosphoramidite 7 which was used for incorporation of 4'-C-hydroxymethyl functionalized thymidine monomers once and twice into 17-mer oligodeoxynucleotides (ODNs). The novel modified ODNs exhibited excellent affinity towards complementary DNA and increased resistance towards 3'-exonucleolytic degradation compared to unmodified ODNs.

Full text of DOI:10.1016/0040-4039(95)00301-R

Products guided by the article

Product name:1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Cas No:165306-22-9

R&D Labs maybe for 165306-22-9

Shanghai ZaiQi Bio-Tech Co., Ltd.,

Contact:+86-21-5482 4098

Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
zhangjiagang bonded areas banggao co;ltd

website:http://www.shunchangchem.com

Contact:0086-13921972933

Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Chinapeptides Co,. Ltd

Contact:+86-021-50792271

Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan

Relevant to this article

Tetraalkoxyphenanthrene-Fused Thiadiazoloquinoxalines: Synthesis, Electronic, Optical, and Electrochemical Properties, and Self-Assembly

Doi:10.1021/acs.joc.7b00084
(2017)
Synthesis of some novel pyrazolopyridooxazine, pyrazoloquinolizines, pyrazoloindolizine and pyrazolopyranopyrimidinone derivatives

Doi:10.14233/ajchem.2014.16002
(2014)
Reinvestigation of the Mechanism of the Acid-Catalyzed Epimerization of Reserpine to Isoreserpine

Doi:10.1021/jo00280a052
(1989)
Aryl-palladium-NHC complex: Efficient phosphine-free catalyst precursors for the carbonylation of aryl iodides with amines or alkynes

Doi:10.1039/c4ob01878h
(2014)
Modification of Receptor Selectivity and Functional Activity in Cholecystokinin Peptoid Ligands

Doi:10.1021/jm00017a022
(1995)
Metallorganische Verbindungen der Lanthanoide XCVIII. Synthese und Strukturaufklaerung von Dichloro(η⁵-2,5-di-tert.-butylpyrrolyl)bis(tetrahydrofuran)ytterbium(III)

Doi:10.1016/0022-328X(95)05495-B
(1995)

Article Doi