Synthesis of oligodeoxynucleotides containing 4'-C-(hydroxymethyl)thymidine: Novel promising antisense molecules

DOI: 10.1016/0040-4039(95)00301-R

Source and publish data:

Tetrahedron Letters p. 2535 - 2538 (1995)

Update date:2022-08-04

Topics:

Authors:

Fensholdt

Thrane Thrane

Wengel Wengel

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Article abstract of DOI:10.1016/0040-4039(95)00301-R

4'-C-(Hydroxymethyl)thymidine derivative 1 was transformed into phosphoramidite 7 which was used for incorporation of 4'-C-hydroxymethyl functionalized thymidine monomers once and twice into 17-mer oligodeoxynucleotides (ODNs). The novel modified ODNs exhibited excellent affinity towards complementary DNA and increased resistance towards 3'-exonucleolytic degradation compared to unmodified ODNs.

Full text of DOI:10.1016/0040-4039(95)00301-R

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