Welcome to LookChem.com Sign In|Join Free

CAS

  • or
(+-)-trans-2-Hydroxy-cyclohexanecarboxylic acid ethyl ester is a chiral organic compound with the molecular formula C9H16O3. It is an ester derivative of cyclohexanecarboxylic acid, featuring a hydroxyl group and a trans double bond. (+-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester is characterized by its unique structure, which includes a six-membered cyclohexane ring with a hydroxyl group at the 2-position and an ester group at the carboxylic acid position. The ethyl ester group provides a pleasant aroma and is often used in the synthesis of fragrances and flavorings. Due to its chiral nature, it exists as a mixture of two enantiomers, which can have different biological activities and properties. (+-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester is of interest in the fields of organic chemistry, pharmaceuticals, and the fragrance industry.

1655-06-7 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1655-06-7 Structure
  • Basic information

    1. Product Name: (+-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester
    2. Synonyms:
    3. CAS NO:1655-06-7
    4. Molecular Formula:
    5. Molecular Weight: 172.224
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1655-06-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (+-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (+-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester(1655-06-7)
    11. EPA Substance Registry System: (+-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester(1655-06-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1655-06-7(Hazardous Substances Data)

1655-06-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1655-06-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,5 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1655-06:
(6*1)+(5*6)+(4*5)+(3*5)+(2*0)+(1*6)=77
77 % 10 = 7
So 1655-06-7 is a valid CAS Registry Number.

1655-06-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (+/-)-trans-2-hydroxy-cyclohexanecarboxylic acid ethyl ester

1.2 Other means of identification

Product number -
Other names rac-trans-2-Hydroxycyclohexancarbonsaeureaethylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1655-06-7 SDS

1655-06-7Relevant articles and documents

Investigation of Electrostatic Interactions towards Controlling Silylation-Based Kinetic Resolutions

Zhang, Tian,Redden, Brandon K.,Wiskur, Sheryl L.

supporting information, p. 4827 - 4831 (2019/08/12)

Electrostatic interactions between a silylated isothiourea intermediate and an ester π system were explored by determining how variations in sterics and electronics affect the selectivity of a silylation-based kinetic resolution. Sterics on the π systems affect the selectivity factors of alkyl 2-hydroxycyclohexanecarboxylates, resulting in a strong correlation of selectivity factors to Charton values. Induction effects of electron-withdrawing substituents on phenyl esters significantly enhance selectivity supporting an edge to face π–π interaction. The linear free energy relationships that were uncovered will aid in future incorporation of intermolecular electrostatic interactions towards controlling asymmetric reactions.

Chemoenzymatic approaches to the synthesis of the (1S,2R)-isomer of benzyl 2-hydroxycyclohexanecarboxylate

Tsunekawa, Ryuji,Hanaya, Kengo,Higashibayashi, Shuhei,Shoji, Mitsuru,Sugai, Takeshi

, p. 84 - 89 (2017/12/06)

We examined ten strains of cultured whole-cell yeasts for the asymmetric reduction of commercially available ethyl 2-oxocyclohexanecarboxylate, and found that the (1S,2S)-stereoisomer of ethyl 2-hydroxycyclohexanecarboxylate was the major stereoisomer produced by Williopsis californica JCM 3600. The ethyl group of the ester was then substituted with a benzyl group with low volatility and increased hydrophobicity to facilitate the isolation of the expected product. Incubation with W. californica furnished benzyl (1S,2S)-2-hydroxycyclohexanecarboxylate (>99.9% ee) in 51.0% yield together with its (1R,2S)-isomer (>99.9% ee) in 35.4% yield. Upon treatment of the same substrate bearing the benzyl ester with a screening kit of purified overexpressed carbonyl reductases (Daicel Chiralscreen OH), two enzymes (E031, E078) furnished the (1R,2S)-isomer as the major product. With another enzyme (E007), the (1S,2R)-isomer was obtained, but its ee was very low (25.6%). The highly enantiomerically enriched (1S,2S)-isomer obtained by W. californica was transformed to the (1S,2R)-isomer (>99.9% ee), whose availability until now has been low, in 43.3% yield over two steps involving tosylation and subsequent inversive attack with tetrabutylammonium nitrite.

BIARYL PYRAZOLES AS NRF2 REGULATORS

-

Page/Page column 455, (2017/08/01)

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

New Route to Stabilize Ruthenium Nanoparticles with Non-Isolable Chiral N-Heterocyclic Carbenes

Martnez-Prieto, Luis Miguel,Ferry, Anglique,Lara, Patricia,Richter, Christian,Philippot, Karine,Glorius, Frank,Chaudret, Bruno

, p. 17495 - 17502 (2016/01/25)

Ru nanoparticles (RuNPs) stabilized by non-isolable chiral N-heterocyclic carbenes (NHCs), namely SIDPhNp ((4S,5S)-1,3-di(naphthalen-1-yl)-4,5-diphenylimidazolidine) and SIPhOH ((S)-3-((1S,2R)-2-hydroxy-1,2-diphenylethyl)-1-((R)-2-hydroxy-1,2-diphenylethyl)-4,5-dihydro-3H-imidazoline), have been synthesized through a new procedure that does not require isolation of the free carbenes. The obtained RuNPs have been characterized by state-of-the-art techniques and their surface chemistry has been investigated by FTIR and solid-state MAS NMR upon the coordination of CO, which indicated the presence of free and reactive Ru sites. Their catalytic activity has been tested in various hydrogenation reactions involving competition between different sites, whereby interesting differences in selectivity were observed, but no enantioselectivity.

Synthesis and characterization of the enantiomerically pure cis- and trans-2,4-dioxa-3-fluoro-3-phosphadecalins as inhibitors of acetylcholinesterase

Waechter, Michael,Rueedi, Peter

experimental part, p. 283 - 294 (2010/04/23)

The title compounds, the P(3)-axially- and P(3)-equatorially-substituted cis- and trans-configured 3-fluoro-2,4-dioxa-3-phosphadecalin 3-oxides (= 3-fluoro-2,4-dioxa-3-phosphabicyclo[4.4.0]decane 3-oxides) have been prepared (ee > 99%) and fully character

Reductions of cyclic β-keto esters by individual Saccharomyces cerevisiae dehydrogenases and a chemo-enzymatic route to (1R,2S)-2-methyl-1-cyclohexanol

Padhi, Santosh Kumar,Kaluzna, Iwona A.,Buisson, Didier,Azerad, Robert,Stewart, Jon D.

, p. 2133 - 2138 (2008/02/11)

Twenty purified dehydrogenases cloned from bakers' yeast (Saccharomyces cerevisiae) and expressed as fusion proteins with glutathione (S)-transferase were tested for their ability to reduce three homologous cyclic β-keto esters. The majority of dehydrogenases reduced ethyl 2-oxo-cyclopentanecarboxylate, yielding a pair of diastereomeric alcohols with consistent (1R)-stereochemistry. Ethyl 2-oxo-cyclohexanecarboxylate reductions afforded only cis-alcohol enantiomers. Ethyl 2-oxo-cycloheptanecarboxylate was accepted by two enzymes in the collection, and both yielded mainly the cis-(1R,2S)-alcohol. Escherichia coli cells overexpressing the YDL124w gene were used in a dynamic kinetic resolution of ethyl 2-oxo-cyclohexanecarboxylate to produce the key intermediate in a chemo-enzymatic synthesis of (1R,2S)-2-methyl-1-cyclohexanol, an important chiral building block.

Carbonylative ring opening of terminal epoxides at atmospheric pressure

Denmark, Scott E.,Ahmad, Moballigh

, p. 9630 - 9634 (2008/03/17)

(Chemical Equation Presented) The carbonylative opening of terminal epoxides under mild conditions has been developed using Co2-(CO) 8 as the catalyst. Under 1 atm of carbon monoxide and at room temperature in methanol, propylene oxide is converted to methyl 3-hydroxybutanoate in up to 89% yield. This transformation is general for many terminal epoxides bearing alkyl, alkenyl, aryl, alkoxy, chloromethyl, phthalimido, and acetal functional groups. The opening takes place without epimerization at the secondary stereocenter.

Rhodium-catalyzed reformatsky-type reaction

Kanai, Kazuo,Wakabayashi, Hitoshi,Honda, Toshio

, p. 2549 - 2551 (2007/10/03)

(equation presented) A novel Reformatsky-type reaction was developed using RhCl(PPh3)3 and diethylzinc. Inter- and intramolecular Reformatsky-type reactions were achieved efficiently under mild reaction conditions to give β-hydroxy esters.

Stereoselective synthesis of novel anti-MRSA tricyclic carbapenems (trinems)

Kanno, Osamu,Kawamoto, Isao

, p. 5639 - 5648 (2007/10/03)

(4S)-Hydroxymethyltrinem 3 was prepared via stereoselective aldol-type reaction with optically pure (R)-2-t-butyldimethylsilyloxymethylcyclohexanone ((R)-16). (4S)-Hydroxymethyltrinem 3 was converted into various kinds of trinem derivatives with anti-MRSA activity by using the Mitsunobu reaction. (C) 2000 Elsevier Science Ltd.

BENZAMIDINE DERIVATIVES SUBSTITUTED BY CYCLIC AMINO ACID AND CYCLIC HYDROXY ACID DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS

-

, (2008/06/13)

This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1655-06-7