1656990-87-2Relevant articles and documents
Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide
Bonomi, Robin,Popov, Vadim,Laws, Maxwell T.,Gelovani, David,Majhi, Anjoy,Shavrin, Aleksandr,Lu, Xin,Muzik, Otto,Turkman, Nashaat,Liu, Renshyan,Mangner, Thomas,Gelovani, Juri G.
, p. 7116 - 7130 (2018)
Sirtuin 1 (SIRT1) is a class III histone deacetylase that plays significant roles in the regulation of lifespan, metabolism, memory, and circadian rhythms and in the mechanisms of many diseases. However, methods of monitoring the pharmacodynamics of SIRT1
Catalyst-Free Aromatic Radiofluorination via Oxidized Iodoarene Precursors
Kwon, Young-Do,Son, Jeongmin,Chun, Joong-Hyun
supporting information, p. 7902 - 7906 (2019/01/04)
Oxidized iodoarenes (OIAs), prepared via mCPBA-mediated oxidation, have been demonstrated as versatile precursors for the synthesis of [18F]fluoroarenes in the absence of catalysts. OIAs have been identified as intermediates in single-pot syntheses of iodonium salts and ylides but have never been recognized as radiofluorination precursors. Here, the isolated OIAs were used without any catalysts to produce functionalized [18F]fluoroarenes, regardless of the electronic nature of the arenes. This method was also applied to the production of radiolabeling synthons for use as aromatic 18F-labeled building blocks.
A general copper-mediated nucleophilic 18F fluorination of arenes
Tredwell, Matthew,Preshlock, Sean M.,Taylor, Nicholas J.,Gruber, Stefan,Huiban, Mickael,Passchier, Jan,Mercier, Joel,Genicot, Christophe,Gouverneur, Veronique
supporting information, p. 7751 - 7755 (2014/08/05)
Molecules labeled with fluorine-18 are used as radiotracers for positron emission tomography. An important challenge is the labeling of arenes not amenable to aromatic nucleophilic substitution (SNAr) with [ 18F]F-. In the
