1660146-37-1

Basic information

• Product Name: C₂₇H₃₀N₂O₄
• Synonyms: C₂₇H₃₀N₂O₄
• CAS NO: 1660146-37-1
• Molecular Weight: 446.546
• Mol File: 1660146-37-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₀N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₀N₂O₄(1660146-37-1)
• EPA Substance Registry System: C₂₇H₃₀N₂O₄(1660146-37-1)

Safety Data

• Hazardous Substances Data: 1660146-37-1(Hazardous Substances Data)

Upstream product

• 1233249-91-6 1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylic acid 
• 1233249-92-7 tert-butyl 4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoate 
• 65412-03-5 4-(2-aminoethyl)tetrahydropyran 
• 1233249-93-8 4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoic acid 
• 1233249-90-5 methyl 1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylate 
• 1233249-89-2 tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide 
• 108052-76-2 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester 

Downstream Products

• 1233248-87-7 2-[1-[[4-[2-(oxan-4-yl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid 

Relevant articles and documents

Isoquinoline derivatives as potent, selective, and orally active CRTH2 antagonists

Synthesis and structure-activity relationship of a novel series of isoquinoline CRTH2 antagonists bearing a methylene linker between the isoquinoline and benzamide moieties were described. Optimization focusing on the substituents of the benzamide portion in the right hand part of the molecule led to the identification of TASP0412098 (9l), which is a potent, selective CRTH2 antagonist (binding affinity: IC50=2.1 nM, functional activity: IC50=12 nM). Compound 9l, which was orally bioavailable in mice and guinea pigs, showed in vivo efficacy after oral administration in a bronchial asthma model of guinea pigs.