16616-38-9

Upstream product

• 2905-65-9 methyl 3-chlorobenzoate 
• 536-74-3 phenylacetylene 
• 535-80-8 3-chlorobenzoate 
• 1128-76-3 3-chloro-benzoic acid ethyl ester 
• 637-44-5 phenylpropyolic acid 
• 7436-90-0 2,2-dibromostyrene 
• 587-04-2 m-Chlorobenzaldehyde 
• 64-18-6 formic acid 
• 625-99-0 3-iodochlorobenzene 
• 201230-82-2 carbon monoxide 
• 108-42-9 3-chloro-aniline 
• 618-46-2 m-Chlorobenzoyl chloride 
• 59931-63-4 1-(3-chlorophenyl)-3-phenyl-prop-2-yn-1-ol 
• 26767-07-7 2-(3-chlorophenyl)-2-oxoacetic acid 

Downstream Products

• 1245504-68-0 (3-chlorophenyl)(2-(4-fluoro-2-nitrophenyl)-5-phenyl-2H-1,2,3-triazol-4-yl)methanone 
• 1245504-69-1 (2-(2-chlorobenzyl)-5-phenyl-2H-1,2,3-triazol-4-yl)(3-chlorophenyl)methanone 
• 58483-29-7 2-(3-chloro-phenyl)-4-phenyl-3H-benzo[b][1,4]diazepine 
• 1172224-91-7 2-(3-chlorophenyl)-4-phenylquinoline 
• 388091-63-2 1-(3-chlorophenyl)-3-phenylpropan-1-one 
• 57736-12-6 1-(3'-chlorophenyl)-3-phenylpropane-1,3-dione 
• 100-47-0 benzonitrile 

Relevant academic research and scientific papers

Metal-Free Promoted CF2/CF3-Difunctionalization of Unactivated Alkenes

An operationally simple radical difluoroalkylation/trifluoromethylation and alkynylation of unactivated alkenes under mild conditions has been developed. Through this protocol, a series of CF2/CF3- substituted linear alkynyl ketones

Palladium(II) on 4 ? Molecular Sieves: A Simple and Reusable Catalyst for the Preparation of Ynones

Abstract: Pd2+ on 4?? molecular sieves support has been prepared and investigated. The catalyst has successfully been used in the reaction of acyl chlorides and terminal alkynes yielding ynones. The catalyst can be reused without significant lo

Synthesis of Isoselenazoles and Isothiazoles from Demethoxylative Cycloaddition of Alkynyl Oxime Ethers

A general method for the synthesis of isoselenazoles and isothiazoles has been developed by the base-promoted demethoxylative cycloaddition of alkynyl oxime ethers using the cheap and inactive Se powder and Na2S as selenium and sulfur sources. This transformation features the direct construction of N-, Se-, and S-containing heterocycles through the formation of N-Se/S and C-Se/S bonds in one-pot reactions with excellent functional group tolerance.

Methylation Alkynylation of Terminal Alkenes via 1,2-Alkynyl Migration Using Dicumyl Peroxide as the Methyl Source

The metal-free oxidative alkene methylation/alkynylation of 1,4-enyn-3-ols with an organic peroxide as the methyl source has been developed, which provides straightforward and practical access to the challenging quaternary-carbon-containing but-3-yn-1-one

Recyclable heterogeneous palladium-catalyzed carbonylative Sonogashira coupling under CO gas-free conditions

A convenient, efficient and practical heterogeneous palladium-catalyzed carbonylative Sonogashira coupling of aryl iodides with terminal alkynes under CO gas-free conditions has been developed by using an MCM-41-supported bidentate phosphine palladium ace

Palladium-catalyzed carbonylative Sonogashira cross-coupling for the synthesis of alkynones with formic acid as the CO source

Abstract: A practical and efficient palladium-catalyzed carbonylative Sonogashira cross-coupling reaction for the synthesis of alkynones from aryl iodides, alkynes, and formic acid as the CO source has been described. Under the assistance of PPh3/I2, formic acid can be used as the CO source for synthesis of alkynones in moderate–good yields. Furthermore, it is also successfully applied for the modification of natural products, such as vindoline and tabersonin, to obtain the corresponding products.

Photocatalytic Annulation-Alkynyl Migration Strategy for Multiple Functionalization of Dual Unactivated Alkenes

A novel photoredox catalysis for multiple functionalization of two different types of unactivated alkenes in a single operation was reported through a conceptually new mode of annulation-alkynyl migration. A wide array of cyclopentane carboxylates were sy

Silver-catalyzed Double Decarboxylative Radical Alkynylation/Annulation of Arylpropiolic Acids with α-keto Acids: Access to Ynones and Flavones under Mild Conditions

Ynones are privileged building blocks in various organic syntheses of heterocyclic derivatives due to their multifunctional nature, and flavones are an important class of natural products with a wide range of biological activities. We describe the catalytic double decarboxylative alkynylation of arylpropiolic acids with α-keto acids. With Ag(I)/persulfate as the catalysis system, the valuable ynones bearing various substituents could be easily obtained. The introduction of hydroxyl substituent on ortho-site of α-keto acids make this strategy further applicable to the construction of flavone derivatives via heteroannulation in moderate to good yields with a similar silver-catalyzed system. The reactions proceed under relatively mild reaction conditions and tolerate a wide variety of functional groups. Control experiments indicated that both the reactions undergo radical processes. (Figure presented.).