16619-10-6Relevant articles and documents
Gram-scale preparation of dialkylideneacetones through Ca(OH)2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH
Zhang, Hao,Han, Mengting,Yang, Chenggen,Yu, Lei,Xu, Qing
, (2018/02/06)
A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)2 as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v) as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level.
Highly selective claisen-schmidt condensation catalyzed by silica chloride under solvent-free reaction conditions
Hazarkhani, Hassan,Kumar, Pradeep,Kondiram, Kadam Sachin,Shafi Gadwal, Ikhlas M.
experimental part, p. 2887 - 2896 (2010/10/20)
Silica chloride serves as a useful catalyst in the cross-aldol condensation, leading to the synthesis of a wide variety of bisarylidene cycloalkanones and chalcones. The catalyst showed high selectivity; self-condensation of ketones was not observed.
