166190-04-1

Usage

Uses

Used in Ophthalmic Applications:
Ethanone, 2-phenoxy-1-[3-(trifluoromethyl)phenyl]is used as an antiviral agent for the treatment of eye infections caused by the herpes simplex virus. It is administered topically in the form of eye drops, which allows for direct delivery to the site of infection, minimizing systemic side effects.
Used in Viral Eye Infection Treatment:
In the application industry of ophthalmology, trifluridin is used as a therapeutic agent for reducing the symptoms and duration of viral eye infections. Its effectiveness in treating these conditions is attributed to its ability to inhibit viral replication, thereby limiting the severity and duration of the infection.
Used in Enhancing Patient Safety:
Ethanone, 2-phenoxy-1-[3-(trifluoromethyl)phenyl]is considered safe for use under medical supervision, ensuring that patients receive the necessary treatment while minimizing the risk of adverse effects. This safety profile makes it a preferred choice for treating viral eye infections, especially in immunocompromised patients or those with other health conditions that may complicate treatment.

Upstream product

• 2003-10-3 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone 
• 108-95-2 phenol 
• 349-76-8 3'-(trifluoromethyl)acetophenone 

Relevant academic research and scientific papers

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

An efficient combinatorial route to substituted 3-phenyl-benzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the need for any chromatographic purification step.

Photochemical Generation of Radical Anions of Photolabile Aryl Ketones

The radical anions of a series of substituted α-(aryloxy)acetophenones have been generated by trapping the solvated electron produced by 355-nm laser-induced photoionization of 4,4'-dimethoxystilbene in either acetonitrile or dimethylformamide (DMF).The radical anion of the parent ketone, α-phenoxyacetophenone, has λmax at 500 nm and decays with a rate constant 7 x 1E5 s-1.This rate constant reflects the rate of β-cleavage to generate phenoxide ion and phenylacyl radical.The rate constant for β-cleavage decreases for ketones with electron donating substituents in the α-aryloxy ring.Substituent effects on the acetophenone ring are in the opposite direction, and many of the 4-substituted (aryloxy)acetophenones have half-lives in excess of 10 μs that reflect a combination of second order processes and are not limited by β-cleavage.The generality of the photoionization/electron trapping method for the generation of radical anions of ketones with short-lived excited states that preclude direct excitation is illustrated by its application to other aryl ketones that undergo α-cleavage, β-phenyl quenching, and intramolecular hydrogen abstraction reactions.