17784-60-0

Basic information

• Product Name: 4-(1H-PYRAZOL-3-YL)PYRIDINE
• Synonyms: 4-(1H-PYRAZOL-3-YL)PYRIDINE;BUTTPARK 17\04-95;4-(1H-pyrazol-3-yl)pyridine(SALTDATA: 0.9HCl);4-(1H-pyrazol-3-yl)pyridine 0.9HCl;4-(PYRAZOL-3-YL)-PYRIDINE;4-(2H-pyrazol-3-yl)pyridine;4-(1H-Pyrazol-3-yl)
• CAS NO: 17784-60-0
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16
• Mol File: 17784-60-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 151-153℃
• Boiling Point: 357 °C at 760 mmHg
• Flash Point: 176.1 °C
• Appearance: /
• Density: 1.214
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.84±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-PYRAZOL-3-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-PYRAZOL-3-YL)PYRIDINE(17784-60-0)
• EPA Substance Registry System: 4-(1H-PYRAZOL-3-YL)PYRIDINE(17784-60-0)

Safety Data

• Hazardous Substances Data: 17784-60-0(Hazardous Substances Data)

Usage

General Description

4-(1H-Pyrazol-3-yl)pyridine is a chemical compound with the molecular formula C10H8N4. It is a pyrazole derivative that contains a pyridine ring. 4-(1H-Pyrazol-3-yl)pyridine is used in the synthesis of various pharmaceutical and agrochemical products. It also has potential applications in the field of organic electronics as a building block for conducting materials. Additionally, 4-(1H-Pyrazol-3-yl)pyridine has been studied for its potential antitumor and antibacterial properties, making it a subject of interest in medicinal chemistry research. Overall, this chemical compound has versatile applications in various industries and has potential for further exploration in the fields of pharmaceuticals and materials science.

InChI:InChI=1/C8H7N3/c1-4-9-5-2-7(1)8-3-6-10-11-8/h1-6H,(H,10,11)

Upstream product

• 123367-27-1 3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one 
• 123367-27-1 (E)-3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 109-94-4 formic acid ethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 68-12-2 N,N-dimethyl-formamide 
• 20007-63-0 5-methyl-3-(4-pyridyl)-1H-pyrazole 

Downstream Products

• 875414-11-2 [2-bromo-4-(3-pyridin-4-yl-pyrazol-1-yl)-phenyl]-(5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)-methanone 
• 1400221-06-8 N-[3-(1-ethyl-3-pyridin-4-yl-1H-pyrazol-4-yl)-phenyl]-hydroxylamine 
• 1400221-08-0 C₁₆H₁₄N₄O₂ 
• 1616091-43-0 1,3,5-tris(3-(pyridin-4-yl)-1H-pyrazol-1-yl)benzene 
• 690262-01-2 1-benzyl-4-(1H-pyrazol-3-yl)-piperidine 
• 1314258-26-8 3-[1-phenyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]benzoic acid 
• 1283092-22-7 4-(4-bromo-1-phenyl-1H-pyrazol-3-yl)pyridine 
• 1314264-02-2 4-(1-phenyl-1H-pyrazol-3-yl)-pyridine 
• 166196-54-9 4-(4-bromo-1H-pyrazol-3-yl)pyridine 
• 401522-15-4 C₆₀H₈₆N₄O₁₆S 
• 401522-11-0 2-(3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethanol 
• 690261-99-5 1-benzyl-4-(1H-pyrazol-3-yl)-1,2,3,6-tetrahydropyridine 

Relevant articles and documents

Finely Resolved Threshold for the Sharp M12L24/M24L48 Structural Switch in Multi-Component MnL2n Polyhedral Assemblies: X-ray, MS, NMR, and Ultracentrifugation Analyses

In the self-assembly of MnL2n polyhedra, the bend angle (θ) of the divalent ligand components determines the final structure. The threshold for the sharp structural switch between M12L24 and M24L48 was finely resolved to within just 4 by demonstrating the exclusive formation of M12L24 cuboctahedra or M24L48 rhombicuboctahedra from two similar ligands with θ values of 130 and 134. This sharp structural switch was fully confirmed by X-ray crystallography, mass spectrometry, NMR spectroscopy, and ultracentrifugation analyses.

Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies

A series of novel teraryl oxazolidinone compounds was designed, synthesized, and evaluated for their antimicrobial activity and toxicities. The compounds with aromatic N-heterocyclic substituents at the 4-position of pyrazolyl ring showed better antibacterial activity against the tested bacteria than other compounds with different patterns of substitution. Among all potent compounds, 10f exhibited promising safety profile in MTT assays and in hERG K+ channel inhibition test. Furthermore, its phosphate was found to be highly soluble in water (47.1 mg/mL), which is beneficial for the subsequent in vivo test. In MRSA systemic infection mice models, 10f phosphate exerted significantly improved survival protection compared with linezolid. The compound also demonstrated high oral bioavailability (F = 99.1%). Moreover, from the results of in vivo toxicology experiments, 10f phosphate would be predicted to have less bone marrow suppression (Chemical Equation).

RAF KINASE INHIBITORS

Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.