16625-79-9Relevant academic research and scientific papers
Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate
Orsy, Gy?rgy,Fül?p, Ferenc,Mándity, István M.
, p. 956 - 961 (2019)
A selective continuous-flow (CF) deuterodehalogenation approach is described performed in propylene carbonate, which is considered as one of the greenest solvents. Various CF technologies are known for hydrodehalogenation reactions; however, they are not
Copper-catalysed low-temperature water-gas shift reaction for selective deuteration of aryl halides
Bartling, Stephan,Beller, Matthias,Bourriquen, Florian,Junge, Kathrin,Li, Wu,Liu, Weiping,Qu, Ruiyang,Rockstroh, Nils
, p. 14033 - 14038 (2021/11/12)
The introduction of deuterium atoms into organic compounds is of importance for basic chemistry, material sciences, and the development of drugs in the pharmaceutical industry, specifically for identification and quantification of metabolites. Hence, methodologies for the synthesis of selectively labelled compounds continue to be a major area of interest for many scientists. Herein, we present a practical and stable heterogeneous copper catalyst, which permits for dehalogenative deuterationviawater-gas shift reaction at comparably low temperature. This novel approach allows deuteration of diverse (hetero)aryl halides with good functional group tolerance, and no reduction of the aromatic rings or other easily reducible formyl and cyano groups. Multi-gram experiments show the potential of this method in organic synthesis and medicinal chemistry.
A convenient method for palladium-catalyzed reductive deuteration of organic substrates using deuterated hypophosphite in D2O
Oba, Makoto
, p. 215 - 219 (2015/05/20)
A convenient method for the deuteration of organic substrates using deuterated hypophosphite as the deuterium source was investigated. Transfer deuteration of organic substrates, such as aromatic halides, alkenes, alkynes, epoxides, and O-benzyl derivativ
