16628-25-4Relevant articles and documents
Two efficient N-acylation methods mediated by solid-supported reagents for weakly nucleophilic heterocyclic amines
Kim, Kyungjin,Le, Kang
, p. 1957 - 1959 (1999)
Two efficient acylation methods utilizing solid-supported reagents have been developed for weakly nucleophilic heterocyclic amines. The novel approaches by chemoselective purification and polymeric-supported reagents facilitate library synthesis of divers
On Water: Metal-Free Synthesis of Highly Functionalized Benzothiazolylidene from ortho-Haloanilines
Saini, Kapil Mohan,Saunthwal, Rakesh K.,Kumar, Shiv,Verma, Akhilesh K.
, p. 2689 - 2698 (2019/03/15)
An environmentally benign, transition-metal-free organic base promoted one-pot cascade synthesis of highly functionalized benzo[d]thiazol-2(3H)-ylidene benzamide in the presence of water was accomplished by three-component reaction of ortho-iodoanilines,
Identification of small-molecule inhibitors of the Aβ-ABAD interaction
Xie, Yuli,Deng, Shixian,Chen, Zhenzhang,Yan, Shidu,Landry, Donald W.
, p. 4657 - 4660 (2007/10/03)
The interaction of amyloid beta peptide (Aβ) and Aβ-binding alcohol dehydrogenase (ABAD) was recently implicated in the pathogenesis of Alzheimer's disease (AD). Using an ELISA-based screening assay, we identified frentizole, an FDA-approved immunosuppressive drug, as a novel inhibitor of the Aβ-ABAD interaction. Analysis of the frentizole structure-activity relationship led to identification of a novel benzothiazole urea with a 30-fold improvement in potency.
