16628-25-4Relevant academic research and scientific papers
Two efficient N-acylation methods mediated by solid-supported reagents for weakly nucleophilic heterocyclic amines
Kim, Kyungjin,Le, Kang
, p. 1957 - 1959 (1999)
Two efficient acylation methods utilizing solid-supported reagents have been developed for weakly nucleophilic heterocyclic amines. The novel approaches by chemoselective purification and polymeric-supported reagents facilitate library synthesis of divers
Copper promoted C-S and C-N cross-coupling Reactions:The synthesis of 2-(N-Aryolamino)benzothiazoles and 2-(N-Aryolamino)benzimidazoles
Shaik, Baji vali,Seelam, Mohan,Tamminana, Ramana,Kammela, Prasad Rao
, p. 3865 - 3874 (2019/06/20)
The synthesis of 2-(N-aryolamino)benzothiazoles and 2-(N-aryolamino)benzimidazoles has been accomplished in the presence of copper catalyst. These reactions involve C-S and C-N cross-coupling reaction. All electron donating and withdrawing substituent's readily underwent the reaction to give target products in good to excellent yield. In addition, the reaction also gave target product in high yield with bulk scale.
On Water: Metal-Free Synthesis of Highly Functionalized Benzothiazolylidene from ortho-Haloanilines
Saini, Kapil Mohan,Saunthwal, Rakesh K.,Kumar, Shiv,Verma, Akhilesh K.
, p. 2689 - 2698 (2019/03/15)
An environmentally benign, transition-metal-free organic base promoted one-pot cascade synthesis of highly functionalized benzo[d]thiazol-2(3H)-ylidene benzamide in the presence of water was accomplished by three-component reaction of ortho-iodoanilines,
6-chloro-2-aminobenzothiazole derivative as well as preparation method and application thereof
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Paragraph 0062; 0063; 0064; 0065; 0066; 0067, (2017/07/19)
The invention discloses a 6-chloro-2-aminobenzothiazole derivative as well as a preparation method and application thereof. The structure of the 6-chloro-2-aminobenzothiazole derivative is shown in a formula (I), wherein R is selected from substituted or
Identification of small-molecule inhibitors of the Aβ-ABAD interaction
Xie, Yuli,Deng, Shixian,Chen, Zhenzhang,Yan, Shidu,Landry, Donald W.
, p. 4657 - 4660 (2007/10/03)
The interaction of amyloid beta peptide (Aβ) and Aβ-binding alcohol dehydrogenase (ABAD) was recently implicated in the pathogenesis of Alzheimer's disease (AD). Using an ELISA-based screening assay, we identified frentizole, an FDA-approved immunosuppressive drug, as a novel inhibitor of the Aβ-ABAD interaction. Analysis of the frentizole structure-activity relationship led to identification of a novel benzothiazole urea with a 30-fold improvement in potency.
