4921-83-9

Basic information

• Product Name: N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide
• Synonyms: 1-Benzoyl-3-(4-chlorophenyl)thiourea;N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide;N-Benzoyl-N'-(p-chlorophenyl)thiourea;USAF K-1477;N-((4-chlorophenyl)carbamothioyl)benzamide;N-{[(4-chlorophenyl)amino]carbonothioyl}benzamide
• CAS NO: 4921-83-9
• Molecular Formula: C₁₄H₁₁ClN₂OS
• Molecular Weight: 290.7679
• Mol File: 4921-83-9.mol
• Article Data: 35

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.38g/cm³
• Refractive Index: 1.698
• CAS DataBase Reference: N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide(4921-83-9)
• EPA Substance Registry System: N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide(4921-83-9)

Safety Data

• Hazardous Substances Data: 4921-83-9(Hazardous Substances Data)

Usage

General Description

N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide, also known as N-(4-Chlorophenyl)thiocarbamoylaniline, is a chemical compound with the molecular formula C13H10ClN3OS. It is a benzamide derivative with a thiocarbonyl group and a 4-chloroaniline moiety. N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide is mainly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other organic compounds. N-[(4-Chlorophenylamino)(thiocarbonyl)]benzamide is a solid, white to off-white powder with a molecular weight of 295.75 g/mol. It is important to handle this compound with proper care and follow safety guidelines, as it may have potential health hazards and environmental impacts.

InChI:InChI=1/C14H11ClN2OS/c15-11-6-8-12(9-7-11)16-14(19)17-13(18)10-4-2-1-3-5-10/h1-9H,(H2,16,17,18,19)

Upstream product

• 106-47-8 4-chloro-aniline 
• 532-55-8 Benzoyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 65-85-0 benzoic acid 

Downstream Products

• 39536-21-5 S-methyl N-(4-chlorophenyl)amidino thioether 
• 82636-15-5 1-(4-Chloro-phenyl)-2-methylsulfanyl-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 82635-89-0 2-[3-(4-Chloro-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 
• 1427783-70-7 (Z)-N-((benzylamino)((4-chlorophenyl)amino)methylene)benzamide 
• 1427783-70-7 (E)-1-benzyl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-72-9 (Z)-1-furfuryl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-72-9 (E)-1-furfuryl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-74-1 (Z)-1-cyclohexyl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-74-1 (E)-1-cyclohexyl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-76-3 (Z)-1-butyl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-76-3 (E)-1-butyl-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-78-5 (Z)-1-(3-(2-oxoazepan-1-yl)propyl)-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 1427783-78-5 (E)-1-(3-(2-oxoazepan-1-yl)propyl)-2-benzoyl-3-(4-chlorophenyl)guanidine 
• 2866-82-2 N-(4-chlorophenyl)benzamide 

Relevant articles and documents

New ferrocenyl guanidines as potent antioxidants, protein kinase inhibitors and cytotoxic agents against human leukemia THP-1 cell line

Six new ferrocenyl guanidines were synthesized and characterized by elemental analysis, FT-IR and 1H and 13C NMR. Compounds 1–6 were screened for antioxidant, protein kinase inhibition, lethality of brine shrimp, and cytotoxicity aga

Iodine-mediated multi-component reactions: Readily access to tetrazoles and guanidines

Environmentally benign syntheses of One-pot sequential reactions of benzoyl chloride with amines followed by the treatment of molecular I2 reagent under basic conditions provide benzoyl tetrazoles and guanidines in moderate to excellent yields. This one-pot synthesis has several advantages such as mild reaction conditions, short reaction time, convenient workup, high yields, using cheap and readily available reagent molecular Iodine. In addition, functional group tolerance has been explored.

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.