1663-35-0Relevant academic research and scientific papers
Highly selective reduction of acyclic β-alkoxy ketones to protected syn-1,3-diols
Cullen, Aaron J.,Sammakia, Tarek
, p. 3143 - 3145 (2004)
(Chemical Equation Presented) The conversion of 1-(2-methoxyethoxy)ethyl- protected β-hydroxy ketones to syn-1,3-ethylidene acetals is effected by Et3SiH and SnCl4. This reaction is proposed to proceed via a cyclic oxocarbenium ion i
Synthesis of beaded poly(vinyl ether) solid supports with unique solvent compatibility
Greenland, Barnaby W.,Liu, Shuyuan,Cavalli, Gabriel,Alpay, Esat,Steinke, Joachim H.G.
, p. 2984 - 2992 (2010)
Poly(vinyl ether) gels SLURPS (Superior Liquid Uptake Resin for Polymer-supported synthesis) with low cross-linking levels have been synthesized for the first time in beaded form using a non-aqueous inverse suspension polymerisation approach. The synthetic protocol was optimized with regards to several parameters including reactions conditions, type and concentration of suspension stabilizer and controlled low temperature addition of co-initiator. Particle size measurements confirm the production of beads with average diameters of 700-950 μm. Optimization of the monomer composition of the poly(vinyl ether) gels resulted in a novel beaded polymer support with considerably improved as well as unique swelling characteristics in solvents ranging from hexane to water. The synthetic utility of the new gel was confirmed by carrying out a set of transformations with complete conversion leading to a useful amino and hydroxy terminated solid-phase precursor resin. Reaction progress could be monitored easily by 1H and 13C gel-phase NMR.
Vinylation of hydroxy-containing cyclic formaldehyde acetals with acetylene
Oparina,Vysotskaya,Parshina,Khil'ko,Gusarova
, p. 1434 - 1437 (2008)
Nucleophilic addition of alcohols having cyclic acetal fragments to acetylene smoothly occurs under relatively mild conditions (KOH, 100-125°C, 1-2 h, initial acetylene pressure 11-12 atm) to give the corresponding vinyl ethers in 80-83% yield.
METHOD FOR REMOVING OR COLLECTING 2-ALKOXYETHANOL, AND METHOD FOR PRODUCING (2-ALKOXYETHYL) VINYL ETHER
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Paragraph 0184-0192, (2019/07/23)
To provide a method capable of easily and efficiently removing a 2-alkoxyethanol from a mixture containing the 2-alkoxyethanol and a (2-alkoxyethyl) vinyl ether while suppressing a decrease in the yield of (2-alkoxyethyl) vinyl ether. A method for removing a 2-alkoxyethanol, including the step of adding one or more azeotropic solvents selected from the group consisting of alkanes having 7 to 8 carbon atoms and cycloalkanes having 7 to 8 carbon atoms to a mixture containing the 2-alkoxyethanol represented by the following formula (1) [in-line-formulae]R—O—CH2CH2OH??(1)[/in-line-formulae]where R represents an alkyl group having 1 to 4 carbon atoms, and a (2-alkoxyethyl) vinyl ether represented by the following formula (2) [in-line-formulae]R—O—CH2CH2O—CH═CH2??(2)[/in-line-formulae]where R has the same meaning as R in the formula (1),and subjecting the resulting mixture to azeotropic distillation.
MANUFACTURING METHOD OF 2-METHOXYETHYL VINYL ETHER
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Paragraph 0023; 0026, (2018/05/24)
PROBLEM TO BE SOLVED: To provide a method for manufacturing method of 2-methoxy ethyl vinyl ether at high purity and efficiently. SOLUTION: There is provided a manufacturing method of 2-methoxy ethyl vinyl ether by reacting acethylene and methylcellosolve in a reaction liquid containing a base, the reaction temperature is 90 to 130°C, the acethylene and methylcellosolve are supplied continuously or intermittently to the reaction liquid and reacted while conducting extraction of the reaction fraction. SELECTED DRAWING: Figure 2 COPYRIGHT: (C)2018,JPOandINPIT
Influence of Boiling on the Radiolysis of Diglyme
Vlasov,Kholodkova,Ponomarev
, p. 312 - 318 (2018/08/01)
The radiolysis of diethylene glycol dimethyl ether (diglyme) in a boiling state has been studied for the first time. Boiling facilitates the cleavage of internal C–O bonds, weakens the cage effect and diglyme regeneration processes, and facilitates the exchange and dimerization reactions of radicals. As compared with radiolysis at room temperature, the amount of unsaturated products of diglyme fragmentation formed during irradiation in the boiling state is smaller by a factor of 4, and the disproportionation products of heavy radicals are found in negligible amounts, if any. The yield of radiolytic decomposition of diglyme under boiling conditions is ~15 molecule/100 eV, which is higher than that at room temperature by a factor of almost 1.5.
PROCESS FOR THE CONVERSION OF SUGARS TO LACTIC ACID AND 2-HYDROXY-3-BUTENOIC ACID OR ESTERS THEREOF COMPRISING A METALLO-SILICATE MATERIAL AND A METAL ION
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Paragraph 0054; 0055; 0056; 0057; 0058, (2017/03/21)
The present invention regards metallo-silicate materials comprising a metal ion selected from one or more of the group consisting of potassium ions, sodium ions, lithium ions, rubidium ions and caesium ions. The materials are useful preparing lactic acid and 2-hydroxy-3-butenoic acid or esters thereof from a sugar.
Synthetic polycarboxylates and proteins hydrogels for drug sustained release and process for the production thereof
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, (2008/06/13)
A hydrogel matrix for sustained release of compounds which are endowed with pharmacological activity is disclosed, said matrix preferably being of protein or polypeptide nature and comprising a synthetic polymer having the formula wherein R = (C1-C12)-alkyl, R1 = (C1-C4)-alkyl, R2 = H (m = 1, 3; n = 1-12) or CH3 (m = 1, n = 1-12), a protein component and the compound which is endowed with pharmacological activity. The process for the preparation of said hydrogel matrix is also disclosed. Such matrices are employed for transcutaneous, transdermal and in particular for ophthalmic routes administration, the ophthalmic route being realized through ophthalmic inserts. A particular application of this invention consists of ophthalmic inserts for sustained release of interferon.
Collisionally Activated Decomposition of Poly(ethylene glycol)s: an Investigation of High-Mass Ion Abundances in the Collisional Activation Technique with Large Molecules
Kiplinger, Jeffrey P.,Bursey, Maurice M.
, p. 342 - 349 (2007/10/02)
The utility of the collisional activation technique in structure determination of ions is limited as parent ion mass increases.Optimum cillisionally activated dissociation yield is often obtained at parent masses of 1000-2000 u, after which daughter ion yield decreases.The apparent decrease in the efficiency of the collisional activation process has been thought of as a degree-of-freedom effect: as new rotational-vibrational modes are added to the parent ion, its lifetime with respect to dissociation increases.We have investigated this effect using an easily characterized system of several poly(ethylene glycol) homologs from the 15-mer to the 35-mer.Observed trends in the collisional activation spectra as parent mass increases support the postulated 'degree-of-freedom' effect in general.The loss of C2H4O from the - parents, a fragmentation which has a high activation barrier, however, actually becomes more favored as the parent ion becomes larger.This effect is explained in terms of statistical rate theory.
