166337-42-4

Basic information

• Product Name: N‐methoxy‐N‐methyl‐2‐phenyl butyramide
• Synonyms: N‐methoxy‐N‐methyl‐2‐phenyl butyramide
• CAS NO: 166337-42-4
• Molecular Weight: 207.272
• Mol File: 166337-42-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N‐methoxy‐N‐methyl‐2‐phenyl butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N‐methoxy‐N‐methyl‐2‐phenyl butyramide(166337-42-4)
• EPA Substance Registry System: N‐methoxy‐N‐methyl‐2‐phenyl butyramide(166337-42-4)

Safety Data

• Hazardous Substances Data: 166337-42-4(Hazardous Substances Data)

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 68641-49-6 bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride 
• 90-27-7 2-Phenylbutyric acid 
• 2294-71-5 methyl 2-phenylbutanoate 
• 36854-57-6 2-Phenylbutyryl chloride 

Downstream Products

• 16282-16-9 1,2-diphenyl-butan-1-one 
• 116057-75-1 idoxifene 

Relevant articles and documents

Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-position in a single reaction via deprotonation, followed by enantioselective protonation. The principle of microscopic reversibility, which has previously rendered this strategy elusive, is overcome by a photoredox deprotonation through single electron transfer and subsequent hydrogen atom transfer (HAT). Specifically, the irradiation of racemic pyridylketones in the presence of a single photocatalyst and a tertiary amine provides nonracemic carbonyl compounds with up to 97% enantiomeric excess. The photocatalyst harvests the visible light, induces the redox process, and is responsible for the asymmetric induction, while the amine serves as a single electron donor, HAT reagent, and proton source. This conceptually simple light-driven strategy of coupling a photoredox deprotonation with a stereocontrolled protonation, in conjunction with an enrichment process, serves as a blueprint for other deracemizations of ubiquitous carbonyl compounds.

Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen

A new enabling technology for the pumping of organometallic reagents such as n-butyllithium, Grignard reagents, and DIBAL-H is reported, which utilises a newly developed, chemically resistant, peristaltic pumping system. Several representative examples of its use in common transformations using these reagents, including metal-halogen exchange, addition, addition-elimination, conjugate addition, and partial reduction, are reported along with examples of telescoping of the anionic reaction products. This platform allows for truly continuous pumping of these highly reactive substances (and examples are demonstrated over periods of several hours) to generate multigram quantities of products. This work culminates in an approach to the telescoped synthesis of (E/Z)-tamoxifen using continuous-flow organometallic reagent-mediated transformations.

4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. STR1 Wherein R 10 and R 20 taken together are: STR2