16635-10-2

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 106-44-5 p-cresol 

Downstream Products

• 75201-02-4 2-[5-(4-Chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-phenol 
• 86882-00-0 2-[2-(4-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-4-methyl-phenol 
• 86691-09-0 2-[5-(4-Chloro-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-phenol 
• 115879-92-0 C₂₂H₁₈ClN₃O₂ 
• 1267528-41-5 3-(2-hydroxy-5-methylphenyl)-5-(p-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide 
• 14166-16-6 2-(4-chlorophenyl)-6-methylchroman-4-one 
• 1266399-49-8 C₁₇H₁₆ClN₃O₂ 
• 1266399-37-4 4-(4-chlorophenyl)-8-methyl-4H-chromeno[4,3-d][1,2,3]selenadiazole 
• 60402-31-5 6-Bromomethyl-2-p-chlorophenylchromone 

Relevant academic research and scientific papers

Iodine-mediated direct synthesis of 3-iodoflavones

Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.

Rapid synthesis of flavone-based monoamine oxidase (MAO) inhibitors targeting two active sites using click chemistry

A new library of flavone derivatives targeting two active sites of monoamine oxidases (“aromatic cage” and substrate cavity) were designed and synthesized using click chemistry (CuAAC reaction) between 6-N3-2-phenyl chromones (Az1–Az2) and a series of alkynes (k1–k20). Their inhibitory activities against MAO isoforms (MAO-A and MAO-B) are evaluated. Compounds with fluorine, amide bonds, or amino bonds have shown better inhibition. The most potent flavone MAO inhibitor studied is Az2k19 (1.6?μm for MAO-A, 2.1?μm for MAO-B), while Az1k15 and Az2k15 displayed better selectivity toward MAO-B (SI?>?10). Docking studies are in accordance with our hypothesis that these inhibitors are most likely located at both the substrate cavity and the “aromatic cage”. Our results show that it is considerable to develop new MAO inhibitors from C6 substitution of flavone derivatives and that these compounds are also potential for the treatment of diseases associated with MAOs.

Absorption and fluorescent studies of 3-hydroxychromones

The synthesis and spectral studies of variously substituted 3-hydroxychromones have been carried out. A key relationship between the structural motif of synthesized 3-hydroxychromones (3-HCs) and their fluorescent properties was found. The chromones substituted with electron-donating group at 4′-position expressed the red shift of the N and T band and also exhibited the increased fluorescent intensity ratio while the chromones with electron-withdrawing group showed the blue shift of the N and T band. Therefore, these 3-HCs may behave as the possible fluorescent probes.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

Synthesis of some new pyrimidines and isoxazolines and their pharmacological activity

The condensation of 5-methyl-2-hydroxy acetophenone 1 with different aromatic aldehydes in anhyd ethanol in presence of strong alkali gave 1-(5′-methyl-2′-hydroxy phenyl-1′-yl)-3-substituted arylidene-2-propen-1-ones (2a-d). Compounds (2a-d) underwent cyc

Studies on ruthenium(III) chalconate complexes containing PPh 3/AsPh3

The reactions of [RuX3(EPh3)3] (X = Cl or Br; E = P or As) with 2′-hydroxychalcones in benzene under reflux led to the formation of [RuX2(EPh3)2(L)] (X = Cl or Br; E = P or As; L = chalcona

Synthesis and cytotoxic activity of 4-aryl-4H-chromeno[4,3-d] [1,2,3] selenadiazoles

Fourteen 4-Aryl-4H-chromeno[4,3-d][1,2,3] selenadiazole derivatives were synthesized by the reaction of fla-vonone-4-semicarbazones with SeO2. The structures of the target compounds 1a-n were elucidated by 1H NMR, IR spectra, ESI-MS and elemental analyses. The preliminary cytotoxic activities of 1a-n against K562, KB, A549, SMC-7721 and SGC-7901 cell lines were evaluated by MTT method, indicating that most compounds displayed moderate to good antiproliferative activities against K562 and KB cell lines. Compounds 1m and 1n, the most potent ones, were promising template for development of novel potent antitumor agents.