166432-28-6

Basic information

• Product Name: Clevidipine
• Synonyms: Clevidipine;levidipine;3-((butyryloxy)Methyl) 5-Methyl 4-(2,3-dichlorophenyl)-2,6-diMethylpyridine-3,5-dicarboxylate;Clevidipine impurity
• CAS NO: 166432-28-6
• Molecular Formula: C21H23Cl2NO6
• Molecular Weight: 456.32
• EINECS: 1592732-453-0
• Mol File: 166432-28-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 539.7 °C at 760 mmHg
• Flash Point: 280.2 °C
• Appearance: White crystalline powder
• Density: 1.289 g/cm³
• Vapor Pressure: 1.03E-11mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Clevidipine(CAS DataBase Reference)
• NIST Chemistry Reference: Clevidipine(166432-28-6)
• EPA Substance Registry System: Clevidipine(166432-28-6)

Safety Data

• Hazardous Substances Data: 166432-28-6(Hazardous Substances Data)

Usage

Uses

Antihypertensive.

Brand name

Clevelox (The Medicines Company).

InChI:InChI=1/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3/t18-/m1/s1

Upstream product

• 33657-49-7 chloromethyl n-butyrate 
• 123853-39-4 (+)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 1346550-30-8 benzylidine tert-butyl ester 
• 404373-25-7 2-acetyl-3-(2',3'-dichlorophenyl)prop-2-enoic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 108-20-3 di-isopropyl ether 
• 1020718-27-7 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester 
• 14205-39-1 methyl 3-aminocrotonate 

Relevant articles and documents

Butyric acid clevidipine preparation method

The invention discloses a preparation method of clevidipine butyrate, comprising the following steps: (1) carrying out one-pot reaction by putting 2,3-dichlorobenzaldehyde, methyl acetoacetate and 3-amino crotonic acid ethyl cyanide in a solvent under the action of a catalyst; (2) carrying out recrystallization to obtain a pure product (+/-)-3-(2-cyanoethyl)-5-methyl-4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid; (3) carrying out a reaction between the pure product and alkali; (4) adding water and hydrochloric acid, and collecting an intermediate from reaction products; and (5) carrying out a reaction between the intermediate and n-chloromethyl butyrate in the presence of an alkaline substance and an iodide catalyst, and finally collecting the target product clevidipine butyrate from reaction products. The preparation method provided by the invention has advantages of high yield, stable product quality and low cost, is simple to operate, and is suitable for industrial product of clevidipine butyrate.

PROCESS FOR PREPARATION OF CLEVIDIPINE AND ITS INTERMEDIATE

The present invention relates to a process for the removal of t-butyl group from t-butyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate to provide-1,4-dihydro-2,6-dimethyl-4-(2',3'-dichorophenyl)-5-methoxycarbonyl-3-pyr

PREPARATION OF DIHYDROPYRIDINES

The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidip