16667-01-9

Basic information

• Product Name: 6-bromo-1-methylnaphthalen-2-ol
• CAS NO: 16667-01-9
• Molecular Formula: C₁₁H₉BrO
• Molecular Weight: 237.0926
• Mol File: 16667-01-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 359.8°C at 760 mmHg
• Flash Point: 171.4°C
• Density: 1.535g/cm³
• Vapor Pressure: 1.12E-05mmHg at 25°C
• Refractive Index: 1.681
• CAS DataBase Reference: 6-bromo-1-methylnaphthalen-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-1-methylnaphthalen-2-ol(16667-01-9)
• EPA Substance Registry System: 6-bromo-1-methylnaphthalen-2-ol(16667-01-9)

Safety Data

• Hazardous Substances Data: 16667-01-9(Hazardous Substances Data)

Upstream product

• 856209-57-9 6-bromo-1-(2,4-dibromo-anilino)-1-methyl-1H-naphthalen-2-one 
• 739360-70-4 C₁₅H₁₆BrNO₂ 
• 30518-34-4 6-bromo-1-((dimethylamino)methyl)naphthalen-2-ol 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 247174-14-7 6-bromo-2-methoxy-1-methyl naphthalene 
• 481071-33-4 6-Bromo-1-[(dimethylamino)methyl]-2-naphthyl acetate hydrochloride 
• 1096-84-0 bis(2-hydroxy-1-naphthyl)methane 
• 858023-45-7 1-anilino-6-bromo-1-methyl-1H-naphthalen-2-one 
• 861354-01-0 1,6-dibromo-1-methyl-1H-naphthalen-2-one 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 856209-89-7 N-(6-bromo-1-methyl-2-oxo-1,2-dihydro-[1]naphthyl)-N-phenyl-acetamide 
• 861354-02-1 1-bromo-1-methylnaphthalen-2(1H)-one 

Downstream Products

• 337521-09-2 1-(6-{[tert-butyl(dimethyl)silyl]oxy}-5-methyl-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 337521-12-7 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-1-methyl-2-naphthol 
• 337521-14-9 6-[1-Hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-propyl)-1-methyl-2-naphthyl Trifluoromethanesulfonate 
• 337521-16-1 methyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-1-methyl-2-naphthoate 
• 337522-91-5 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl-1-methyl-2-naphthamide 
• 430472-54-1 methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate 
• 430472-69-8 7-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one 
• 430472-50-7 7-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one 
• 1285532-66-2 7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one 
• 1567351-13-6 3',6-dimethoxy-N-(5-methyl-6-((1-methylpiperidin-4-yl)oxy)naphthalen-2-yl)-[1,1'-biphenyl]-3-carboxamide 
• 247174-14-7 6-bromo-2-methoxy-1-methyl naphthalene 
• 6968-28-1 4-bromophthalic acid 

Relevant articles and documents

Organocatalytic Asymmetric Dearomatization Reaction for the Synthesis of Axial Chiral Allene-Derived Naphthalenones Bearing Quaternary Stereocenters

The highly regio-, diastereo-, and enantioselective dearomatization reaction of 1-substituted 2-naphthols and β,γ-alkynyl-α-imino esters with complete atom economy is disclosed via chiral phosphoric acid catalysis. This protocol provides facile and effici

Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors

Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity.

Substituted naphthyl benzothiophene acids

The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them