16673-80-6

Basic information

• Product Name: 4H-1,3-Oxazin-4-one, 6-methyl-2-phenyl-
• CAS NO: 16673-80-6
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Mol File: 16673-80-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4H-1,3-Oxazin-4-one, 6-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Oxazin-4-one, 6-methyl-2-phenyl-(16673-80-6)
• EPA Substance Registry System: 4H-1,3-Oxazin-4-one, 6-methyl-2-phenyl-(16673-80-6)

Safety Data

• Hazardous Substances Data: 16673-80-6(Hazardous Substances Data)

Upstream product

• 72324-39-1 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 825-60-5 benzimidic acid ethyl ester 
• 3283-23-6 N-benzoylacetoacetamide 
• 123-54-6 acetylacetone 
• 4461-33-0 benzoyl isocyanate 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 98057-84-2 6-Methyl-2-(2-oxo-tetrahydro-pyran-3-yl)-2-phenyl-2,3-dihydro-[1,3]oxazin-4-one 
• 141883-46-7 3-acetyl-5-ethoxycarbonyl-4-ethoxycarbonylmethylene-6-phenyl-2-pyridone 
• 98057-77-3 6-Methyl-2-phenyl-2-(1,1,3-trimethyl-2-oxo-butyl)-2,3-dihydro-[1,3]oxazin-4-one 
• 497059-17-3 3-acetyl-4-amino-5-(3-methyl-5-isoxazolyl)-6-phenyl-2-pyridone 
• 881192-17-2 3-acetyl-4-hydroxy-5-(3-methyl-5-isoxazolyl)-6-phenyl-2-pyridone 
• 497059-13-9 3-acetyl-4-methyl-5-(3-methyl-5-isoxazolyl)-6-phenyl-2-pyridone 
• 497059-15-1 3-acetyl-5-(3-methyl-5-isoxazolyl)-4,6-diphenyl-2-pyridone 
• 93969-45-0 N-[(Z)-3-Oxo-1-(2-oxo-azepan-3-yl)-but-1-enyl]-benzamide 
• 98057-85-3 6-Methyl-2-(2-oxo-oxepan-3-yl)-2-phenyl-2,3-dihydro-[1,3]oxazin-4-one 
• 93969-53-0 8-Acetyl-5-phenyl-2,3,4,6-tetrahydro-1H-[1,6]naphthyridin-7-one 
• 66301-99-3 5-benzoylamino-3-methylisoxazole 
• 66347-71-5 1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-propan-2-one oxime 
• 80628-80-4 5-acetonyl-3-phenyl-1,2,4-oxadiazole 
• 63557-61-9 7,7-dimethoxy-4-methyl-6-phenyl-5-oxa-1-aza-bicyclo[4.2.0]oct-3-en-2-one 

Relevant articles and documents

Facile and Convenient Synthesis of 2,6-Disubstituted 4H-1,3-Oxazin-4-one Derivatives

Facile and convenient methods for the preparation of a variety of 2,6-disubstituted 4H-1,3-oxazin-4-ones 3 by three complementary methods are described. Treatment of the branched aliphatic imidate 2c,d with diketene 1 in the presence of a catalytic amount of acetic acid affords 2-substituted 6-methyl-1,3-oxazin-4-ones 3c,d, whereas the unbranched imidate 2b,e gave oxazines 3b,e and pyrimidines 4b,e (Method A). The reaction of acyl Meldrum's acid 5 with imidate 2 afford 2,6-disubstituted oxazine 3, though the alkylimidate with acetyl Meldrum's acid yielded 3 and 5-acetyl-1,3-oxazine-4,6-dione 8 (Method B). The cylodehydration of acylacetylcarboxamide 13 with acid, such as 70% perchloric acid or fluorosulfonic acid, afforded 1,3-oxazines 3 (Method C).