16673-85-1Relevant articles and documents
REACTION OF 3-AMINOCROTONAMIDE WITH NITRILES
Kato, Tetsuzo,Chiba, Takuo,Sasaki, Makoto
, p. 577 - 580 (2007/10/02)
The reaction of 3-aminocrotonamide (5) with some nitriles, such as acetonitrile, propiononitrile, iso-butyronitrile, and benzonitrile, gave the corresponding 2-substituted 6-methyl-4(3H)-pyrimidones (2a-2d).Phenylacetonitrile reacted with (5) to give 2-benzyl-6-methyl-4(3H)-pyrimidone (7) and 6-amino-4-methyl-5-phenyl-2(1H)-pyridone (8a).Malononitrile, however, reacted with (5) to afford 6-amino-5-cyano-4-methyl-2(1H)-pyridone (8b).