166758-23-2

Usage

Chemical structure

A cyclopentane ring with two silicon atoms and a nitrogen atom, a 3-fluorophenyl group, and four methyl groups.

Composition

Contains carbon (C), hydrogen (H), silicon (Si), nitrogen (N), and fluorine (F) atoms.

Molecular weight

Approximately 287.5 g/mol

Potential applications

a. Organic and inorganic chemistry
b. Synthesis of novel materials
c. Pharmaceutical research and drug development

Unique structure

The presence of silicon and nitrogen atoms in the cyclopentane ring, along with the 3-fluorophenyl group, provides a unique structure for potential chemical and biological activities.

Biological activities

Further research is needed to determine the compound's potential biological activities and its effects on living organisms.

Research and studies

Additional research and studies are required to fully understand the properties, potential uses, and safety of 1-Aza-2,5-disilacyclopentane, 1-(3-fluorophenyl)-2,2,5,5-tetramethyl-.

Stability

The stability of the compound under various conditions (e.g., temperature, pressure, and exposure to light) is not provided and would require further investigation.

Solubility

Information on the solubility of the compound in different solvents is not provided and would need to be determined through experimentation.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 13528-93-3 1,2-bis-(chlorodimethylsilyl)ethane 

Downstream Products

• 1027388-02-8 4-[2-Fluoro-4-(2,2,5,5-tetramethyl-[1,2,5]azadisilolidin-1-yl)-phenyl]-pyridine 
• 371195-26-5 3-fluoro-4-[4-(hydroxy)tetrahydrothiopyran-4-yl]benzenamine 
• 803687-70-9 2-{1-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluoro-phenyl]-1H-[1,2,3]triazol-4-ylmethyl}-isoindole-1,3-dione 
• 803687-79-8 C-{1-[3-fluoro-4-(1,1-dioxo-1,2,3,6-tetrahydro-1λ6-thiopyran-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl}-methylamine 
• 803687-75-4 C-{1-[3-fluoro-4-(1-oxo-1,2,3,6-tetrahydro-1λ4-thiopyran-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl}-methylamine 
• 803687-71-0 C-{1-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluoro-phenyl]-1H-[1,2,3]triazol-4-yl}-methylamine 
• 803687-61-8 C-{1-[4-(3,6-dihydro-2H-pyran-4-yl)-3-fluoro-phenyl]-1H-[1,2,3]triazol-4-yl}-methylamine 

Relevant academic research and scientific papers

NOVEL ANTIINFECTIVE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS

The present invention provides novel triazole compounds of formula (I), their pharmaceutically acceptable salts and their pharmaceutical compositions, where all symbols are as defined in the specification

Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings

A compound of the formula (I): STR1 or pharmaceutical acceptable salts thereof wherein X is NR1, S(O)g, or O; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is --(CH2)h -- aryl, --COR1--1, --COOR1-2, --CO--(CH2)h --COR1--1, C1-6 alkyl sulfonyl, --SO2 --(CH2)h --aryl, or --(CO)i --Het; R2 is H, C1-6 alkyl, --(CH2)h --aryl, or halo; R3 and R4 are the same or different and are H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.

Regioselective Metalation of Fluoroanilines. An Application to the Synthesis of Fluorinated Oxazolidinone Antibacterial Agents

The regioselective para lithiation of 3-fluoro- and 3,5-difluoroaniline stabase derivatives is described.These intermediates were subjected to a reaction sequence involving (1) transmetalation with zinc chloride, (2) a palladium-catalyzed coupling reaction with various pyridyl bromides, and (3) removal of the stabase protecting group, to generate fluorinated 4-(pyridyl)anilines.These compounds are key subunits for the synthesis of selected fluorinated oxazolidinone antibacterial agents.Representative applications of these intermediates to the synthesis of three potent oxazolidinone analogues are discussed.One facet of the described procedure involves a unique iodocyclocarbamation reaction featuring a pyridine additive.