166758-24-3

Upstream product

• 372-19-0 meta-fluoroaniline 
• 1214355-32-4 4-(2-fluoro-4-nitrophenyl)pyridine 
• 185331-69-5 1-bromo-2-fluoro-4-nitrobenzene 
• 181219-01-2 4-pyridineboronic acid pinacol ester 
• 166758-23-2 1-(3-fluorophenyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane 
• 1027388-02-8 4-[2-Fluoro-4-(2,2,5,5-tetramethyl-[1,2,5]azadisilolidin-1-yl)-phenyl]-pyridine 

Downstream Products

• 166758-28-7 (+/-)-5-(Azidomethyl)-3-<4-(4-pyridyl)-3-fluorophenyl>-2-oxazolidinone 
• 166758-30-1 N-Allyl-N-(benzyloxycarbonyl)-4-(4-pyridyl)-3-fluoroaniline 
• 166758-32-3 (+/-)-5-(Iodomethyl)-3-<4-(4-pyridyl)-3-fluorophenyl>-2-oxazolidinone 
• 166758-27-6 N-(Benzyloxycarbonyl)-4-(4-pyridyl)-3-fluoroaniline 

Relevant academic research and scientific papers

Discovery of lipoic acid-4-phenyl-1: H -pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity

A series of lipoic acid (LA) and 4-phenyl-1H-pyrazole hybrids as bifunctional Rho-associated kinase (ROCK) inhibitors were designed, synthesized and evaluated. Compound 15 is identified to be a novel potent bifunctional ROCK inhibitor with antioxidant activity and neuroprotection.

Regioselective Metalation of Fluoroanilines. An Application to the Synthesis of Fluorinated Oxazolidinone Antibacterial Agents

The regioselective para lithiation of 3-fluoro- and 3,5-difluoroaniline stabase derivatives is described.These intermediates were subjected to a reaction sequence involving (1) transmetalation with zinc chloride, (2) a palladium-catalyzed coupling reaction with various pyridyl bromides, and (3) removal of the stabase protecting group, to generate fluorinated 4-(pyridyl)anilines.These compounds are key subunits for the synthesis of selected fluorinated oxazolidinone antibacterial agents.Representative applications of these intermediates to the synthesis of three potent oxazolidinone analogues are discussed.One facet of the described procedure involves a unique iodocyclocarbamation reaction featuring a pyridine additive.