166895-16-5Relevant academic research and scientific papers
From five- to six-membered rings: 3,4-Diarylquinolinone as lead for novel p38MAP kinase inhibitors
Peifer, Christian,Kinkel, Katrin,Abadleh, Mohammed,Schollmeyer, Dieter,Laufer, Stefan
, p. 1213 - 1221 (2007)
In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38αMAPK IC50 of 1.8 μM. By keeping the common vicinal pyridine/4-F-phenyl
NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION
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, (2021/06/04)
The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.
