16691-26-2

Upstream product

• 67-56-1 methanol 
• 98591-60-7 5-phenyl-1,3,4-oxadiazole-2-carbonyl chloride 
• 199938-26-6 methyl 2-benzoylhydrazinoacetate 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 613-94-5 benzoic acid hydrazide 
• 74-88-4 methyl iodide 

Downstream Products

• 1383581-79-0 N-hydroxy-5-phenyl-1,3,4-oxadiazole-2-carboxamide 

Relevant academic research and scientific papers

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: Concurrent optimization of enzyme inhibitor potency and selectivity

The concurrent implementation of a proteome-wide serine hydrolase selectivity screen with traditional efforts to optimize fatty acid amide hydrolase (FAAH) inhibition potency led to the expedited discovery of a new class of exceptionally potent (Ki 100-fold selective) inhibitors. The iterative inhibitor design and evaluation with assistance of the selectivity screen served to differentiate otherwise indistinguishable inhibitors permitting the simultaneous optimization of potency and selectivity. Significantly, the simultaneous assessment of all potential competitive enzymes with the selectivity screen does not require the use of expressed or purified enzymes or a competitive substrate, no modification of the inhibitors is required, and the relative potency for competitive enzymes can be quantified (IC50's) including those that lack known substrates or function.

Oxidation of sp3C—H bonds in N-alkylhydrazides: Access to 2,5-disubstituted 1,3,4-oxadiazole derivatives

The oxidation of sp3C[sbnd]H bonds in N-alkylhydrazides was achieved en route to the efficient synthesis of a broad series of 1,3,4-oxadiazoles. Mechanistic studies have revealed that N-acylhydrazone is a key intermediate in this catalytic transformation.

C-H carboxylation of heteroarenes with ambient CO2

The C-H carboxylation of heteroarenes was achieved under transition metal-free reaction conditions with naturally abundant CO2 as the C1 source at relatively low temperature. The C-H carboxylation was mediated by KOt-Bu at atmospheric pressure

Hydroxamic Acids as Potent Inhibitors of FeII and MnII E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate-EcMetAP-Mn Complexes

New series of acids and hydroxamic acids linked to five-membered heterocycles including furan, oxazole, 1,2,4- or 1,3,4-oxadiazole, and imidazole were synthesized and tested as inhibitors against the FeII, CoII, and MnII f

OXADIAZOLE KETONE INHIBITORS OF FATTY ACID AMIDE HYDROLASE

Certain oxadiazole ketone compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity.